Xiaojiang Chen
教授
Center of Excellence in Structural Biology
University of Southern California;Center of Excellence in NanoBiophysics, University of Southern California;Department of Chemistry, College of Letters, Arts and Sciences, University of Southern California;Department of Biological Sciences, College of Letters, Arts and Sciences, University of Southern California
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基本信息
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个人简介
Description of Research
Summary Statement of Research Interests
Dr. Xiaojiang Chen's combined expertise in Molecular and Cell Biology, Biochemistry, and Structural Biology (X-ray, EM) enables him to study critical questions in DNA replication/repair, Cancer Biology and Immunology at molecular/cellular levels. He has done landmark work on viral replication and viral oncogenes (such as SV40 large tumor antigen, EBV gp350), as well as crucial DNA modifying enzymes which play key roles in genomic stability, cancer, and immunity. His current research interests are (1) APOBEC family of cytidine deaminases (DNA mutases) involved in cancer and immune responses to viruses (HIV, HPV, HBV); (2) DNA/RNA transaction enzymes, including helicases, polymerases/primase for DNA replication and repair which are involved in genomic stability, cell proliferation, and cancer; (3) viral oncoproteins and cellular tumor suppressors; (4) nano-particle assembly for targeted drug delivery.
Summary Statement of Research Interests
Dr. Xiaojiang Chen's combined expertise in Molecular and Cell Biology, Biochemistry, and Structural Biology (X-ray, EM) enables him to study critical questions in DNA replication/repair, Cancer Biology and Immunology at molecular/cellular levels. He has done landmark work on viral replication and viral oncogenes (such as SV40 large tumor antigen, EBV gp350), as well as crucial DNA modifying enzymes which play key roles in genomic stability, cancer, and immunity. His current research interests are (1) APOBEC family of cytidine deaminases (DNA mutases) involved in cancer and immune responses to viruses (HIV, HPV, HBV); (2) DNA/RNA transaction enzymes, including helicases, polymerases/primase for DNA replication and repair which are involved in genomic stability, cell proliferation, and cancer; (3) viral oncoproteins and cellular tumor suppressors; (4) nano-particle assembly for targeted drug delivery.
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Protein & cell (2024)
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