基本信息
浏览量:4
职业迁徙
个人简介
Research Interests
Our research aims to understand how mechanics and biochemical signalling are integrated across multiple scales to ensure robust tissue morphogenesis and patterning in early mammalian development. To address this question, we focus on understanding mammalian oogenesis, the formation of eggs (oocytes) that provide the bulk genetic and cytoplasmic materials for successful reproduction. In our lab, we combine multidisciplinary approaches such as deep tissue imaging, biophysics, molecular genetics and mathematical modelling to understand the mechanical and molecular mechanisms regulating oogenesis. We also investigate how tissue hydraulics (fluid pressure) triggers mechano-signaling pathways to impact oocyte development and cellular functions in other developmental and physiological contexts. The ultimate goal of the lab is to extend these understanding to other mammalian species and identify common principles underlying oogenesis. A quantitative understanding of the mechanical aspects of oogenesis will lead to new understanding in reproductive biology and ageing, with potential implications in assisted reproductive technology and the enhancement of human reproductive lifespan.
Our research aims to understand how mechanics and biochemical signalling are integrated across multiple scales to ensure robust tissue morphogenesis and patterning in early mammalian development. To address this question, we focus on understanding mammalian oogenesis, the formation of eggs (oocytes) that provide the bulk genetic and cytoplasmic materials for successful reproduction. In our lab, we combine multidisciplinary approaches such as deep tissue imaging, biophysics, molecular genetics and mathematical modelling to understand the mechanical and molecular mechanisms regulating oogenesis. We also investigate how tissue hydraulics (fluid pressure) triggers mechano-signaling pathways to impact oocyte development and cellular functions in other developmental and physiological contexts. The ultimate goal of the lab is to extend these understanding to other mammalian species and identify common principles underlying oogenesis. A quantitative understanding of the mechanical aspects of oogenesis will lead to new understanding in reproductive biology and ageing, with potential implications in assisted reproductive technology and the enhancement of human reproductive lifespan.
研究兴趣
论文共 31 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Arikta Biswas,Yuting Lou, Boon Heng Ng, Kosei Tomida, Sukhada Darpe,Zihao Wu, Thong Beng Lu, Isabelle Bonne,Chii Jou Chan
biorxiv(2024)
biorxiv(2023)
biorxiv(2023)
Seminars in cell & developmental biology (2022): 124-133
Seminars in cell & developmental biology (2022): 108-109
C. Bevilacqua, S. Hambura, L. Wang,C. J. Chan,M. Eguren, J. M. Gomez Elliff, A. Diz-Muñoz,R. Prevedel
user-60d14cd84c775e0497060202(2021)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn