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The nervous system and the immune system are the two large sensory units of the body, which perpetually monitor tissue integrity and mount effector responses upon disturbance of tissue hemostasis. However, how these two sensory systems exchange information and coordinate tissue protective responses remains elusive. Our research has recently exposed signaling pathways, by which the nervous system regulates innate lymphoid cells (ILCs) and type 2 immune responses via the production of neuropeptides (neuromedin U) and neurotransmitters (norepinephrine). ILCs are an emerging population of tissue-resident innate immune cells enriched at mucosal barriers, which can mount either protective or detrimental immune response at barrier surfaces. While we begin to understand some of the tissue-specific cues, which regulate immune activation at barrier surfaces, neuronal regulation of immune responses is still almost a black box. In order to systematically investigate neuro-immune crosstalk at mucosal surfaces in health and disease, we have developed elegant genetic tools, which allow experimental manipulation of neurons and ILCs. Taken together, combing cutting-edge technologies in the fields of immunology, neuroscience and genomics, will enable us to conceptually understand neuro-immune interaction and uncover signaling pathways that have the potential to be therapeutically harnessed.
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Nature reviews. Immunologyno. 4 (2023): 294-302
Ivo Röwekamp, Laura Maschirow,Anne Rabes, Facundo Fiocca Vernengo,Gitta Anne Heinz,Mir-Farzin Mashreghi,Sandra Caesar, Miha Milek, Anna Carolina Fagundes Fonseca,Sandra-Maria Wienhold,Geraldine Nouailles,Ling Yao,
biorxiv(2023)
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Cell reportsno. 3 (2023): 112269-112269
Frontiers in immunology (2023): 1294936
JOURNAL OF INVESTIGATIVE DERMATOLOGYno. 12 (2023): 2456-+
Johannes Steffen,Stefanie Ehrentraut,Ute Bank,Aindrila Biswas,Caio Andreeta Figueiredo,Oliver Hölsken,Henning Peter Düsedau, Vladyslava Dovhan,Laura Knop, Jacqueline Thode,Silvina Romero-Suárez,Carmen Infante Duarte,
crossref(2022)
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