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个人简介
Our most recent studies have concentrated on a novel pathway and precursor lesion for ovarian serous carcinogenesis that arises in the distal fallopian tube. Recognizing that women with mutations in BRCA1 or BRCA2 are at risk for both tubal and ovarian cancer, we have been testing the hypothesis that many cases of the most lethal form of ovarian cancer – ovarian surface or peritoneal serous carcinoma – originate from the tubal fimbria. To do so, we developed a protocol for sectioning and extensively examining the fimbriated end (SEE-FIM). Initial studies of BRCA+ women indicate that the majority of cancers detected in prophylactic salpingo-oophorectomy specimens originate from this location, and have been corroborated in collaborative follow-up studies (Medieros et al 2006, Callahan et al 2007). We have identified early tubal cancers in approximately one-half of women with peritoneal and ovarian serous carcinomas (irrespective of BRCA status) and have proposed the fimbria as the origin for these tumors (Kindelberger et al 2007, Carlson, Miron et al, in press). Recently, we characterized a novel precursor to pelvic serous carcinoma that is present in benign appearing mucosa in the distal fallopian tube, which we term the “p53 signature” (Lee, Miron et al, 2007). From this collection of data, we have formulated a “Serous carcinogenic sequence in the distal fallopian tube (Jarboe et al 2008). In collaboration with Drs. Shelley Tworoger, Daniel Cramer and Judy Garber, we are showing for the first time that the tubal p53 signature shares several risk factors with ovarian cancer, further supporting its role as a precursor to or surrogate marker for, pelvic serous cancer. We intend to further characterize this entity and target the serous carcinogenic sequence for early detection and possibly, prevention. This work has been supported by the existing ovarian cancer SPORE (Daniel Cramer PI) and grants from the National Cancer Institute and Columbia Hospital for Women Research Foundation (C. Crum).
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Wa Xian,Frank McKeon,Christopher Crum,Jaffer Ajani,Peter Davies,Matthew Vincent,William Bachovchin, Hung-Sen Lai, Shuang Pan, Amber Su,Ashley Hoffman, Raul Caballero Montes,
Cancer Researchno. 6_Supplement (2024): 1874-1874
Wa Xian,Frank McKeon,Yusuke Yamamoto, Melika Khorrami, Melina Khorrami, Zaal Mory, Jeremy Siegelman, Amber Su, Raul Caballero Montes,Ashley Hoffman,Jaffer Ajani,Christopher Crum,
Cancer Researchno. 6_Supplement (2024): 6099-6099
Wa Xian,Frank McKeon,Christopher Crum,Jaffer Ajani,Peter Davies, Matthew Vincent,William Bachovchin, Hung-Sen Lai, Shuang Pan, Melina Khorrami, Melika khorrami, Raul caballero Montes,
Cancer Researchno. 6_Supplement (2024): 4654-4654
Amir Dehghani, Chrystalle Carreon,Fabiola Medeiros, Marisa Nucci,Christopher Crum, Jason Hornick,W. Glenn McCluggage,David Kolin
LABORATORY INVESTIGATIONno. 3 (2023): S886-S887
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American journal of respiratory and critical care medicineno. 9 (2023): 930-943
Ju-Yoon Yoon,David Chapel,Azra Ligon, Rebecca Ramesh, Aarti Sharma,Grace Neville, Amir Dehghani,Christopher Crum
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Pamoda Galhenage,Yunlan Zhou, Erica Perry,Brenda Loc, Kelly Fietz,Sonia Iyer,Ferenc Reinhardt, Tiego Da Silva,Vladimir Botchkarev, Jie Chen,Christopher P. Crum,Robert A. Weinberg,
Cell Reportsno. 10 (2023): 113144-113144
Wa Xian, Jennifer Lin, Mona Oraei,Frank McKeon,Shan Wang,Jaffer A. Ajani,Christopher P. Crum,William W. Bachovchin, Melina Khorrami, Alice Su,Mohammadhadi Khorrami,Shumei Song,
Cancer Researchno. 7_Supplement (2023): 2670-2670
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American Registry of PathologyArlington, Virginia eBooks (2023)
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