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The main focus of our laboratory is developing a better understanding of how key mutations in gliomas alter their biological characteristics, and how best to exploit specific weaknesses that such mutations often impart. In particular, our laboratory focuses on mutant isocitrate dehydrogenase 1 (mutIDH1), which is present in the vast majority of WHO grade II and III gliomas. This mutation has profound effects on the epigenome and metabolome, yet produces tumors that are markedly less aggressive. Our work indicates that mutIDH1 also dramatically alters the glioma’s micro-environmental landscape by preventing the thrombosis-necrosis phenomenon that is characteristic of IDH1 wild-type gliomas.
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论文共 483 篇作者统计合作学者相似作者
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Nature Communicationsno. 1 (2024): 1-20
Victor Andrés Arrieta, Jasim K. Benotmane,Junfei Zhao, Silpol Dhiantravan,David Hou, Joshua L. Katz, Si Wang,Brandyn Castro, Surya Pandey, Meghan E. Cholak, Yu Han,Chetan Bettegowda,
Neurosurgeryno. Supplement_1 (2024): 190-190
Hinda Najem,Victor A Arrieta,Joseph Duffy,Shashwat Tripathi,Markella Zannikou, Silpol Dhiantravan,Jason Miska,Kathleen McCortney,Alicia Steffens,Jordain Walshon,Catalina Lee Chang, Nader S Dahdaleh,
Annals of case reportsno. 1 (2024)
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The Journal of clinical investigationno. 4 (2024)
Victor Andrés Arrieta,Andrew Gould,Kwang-Soo Kim,Karl Habashy,Crismita Dmello,Christina Amidei, Cristal G. Gómez,Daniel Zhang,Ruth Saganty,Li Chen, Surya Pandey, Meghan E. Cholak,
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Shashwat Tripathi, Cody L. Nathan, Matthew C. Tate,Craig M. Horbinski, Jessica W. Templer, Joshua M. Rosenow, Timothy L. Sita, Charles D. James,Benjamin Deneen, Stephen D. Miller,Amy B. Heimberger
JCI INSIGHTno. 1 (2024)
Victor A. Arrieta,Johnny Duerinck,Kirsten B. Burdett, Karl J. Habashy,Wietse Geens,Andrew Gould,Julia K. Schwarze,Crismita Dmello,Kwang-Soo Kim,Ruth Saganty,Li Chen, Alberto Moscona,
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