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Research Summary/Interests
Biological and biochemical nature of immune self-tolerance
T cell immune tolerance
T cell clonal expansion
Breakdown of B cell tolerance during autoimmune disease development
Rheumatoid Arthritis
Systemic Lupus Erythematosus
Current Research Efforts:
Autoimmunity develops as the consequence of a loss of tolerance to self-antigens. Investigations carried out by Dr. Daniel Mueller are leading to a better understanding of the biological and biochemical nature of immune self-tolerance. Of particular interest are those factors that determine whether prolonged and continuous antigen stimulation of a T cell will lead to an increase in the clone size and the development of protective (or pathological) effector function, or alternatively lead to functional inactivation (anergy) and T regulatory cell (Treg) differentiation. To approach this problem, Mueller's research team is currently using an assortment of genomics and bioinformatics techniques (scRNA-Seq, ATAC-Seq) to characterize gene regulatory patterns in CD4 T cells that are associated with anergy induction and Foxp3+ Treg generation. Candidate gene regulators are being interrogated within neonatal mice--a time at which peripheral tolerance induction is essential for the avoidance of autoimmunity.
Biological and biochemical nature of immune self-tolerance
T cell immune tolerance
T cell clonal expansion
Breakdown of B cell tolerance during autoimmune disease development
Rheumatoid Arthritis
Systemic Lupus Erythematosus
Current Research Efforts:
Autoimmunity develops as the consequence of a loss of tolerance to self-antigens. Investigations carried out by Dr. Daniel Mueller are leading to a better understanding of the biological and biochemical nature of immune self-tolerance. Of particular interest are those factors that determine whether prolonged and continuous antigen stimulation of a T cell will lead to an increase in the clone size and the development of protective (or pathological) effector function, or alternatively lead to functional inactivation (anergy) and T regulatory cell (Treg) differentiation. To approach this problem, Mueller's research team is currently using an assortment of genomics and bioinformatics techniques (scRNA-Seq, ATAC-Seq) to characterize gene regulatory patterns in CD4 T cells that are associated with anergy induction and Foxp3+ Treg generation. Candidate gene regulators are being interrogated within neonatal mice--a time at which peripheral tolerance induction is essential for the avoidance of autoimmunity.
研究兴趣
论文共 205 篇作者统计合作学者相似作者
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Francesca R Donnellan,Vamseedhar Rayaprolu,Pramila Rijal,Victoria O'Dowd,Amar Parvate,Heather Callaway,Chitra Hariharan, Dipti Parekh,Sean Hui,Kelly Shaffer,Ruben Diaz Avalos,Kathryn Hastie,Lisa Schimanski,Helena Müller-Kräuter, Thomas Strecker,Ariane Balaram, Peter Halfmann,Erica Ollmann Saphire,Daniel J Lightwood,Alain R Townsend,Simon J Draper
bioRxiv : the preprint server for biology (2024)
The Journal of experimental medicineno. 12 (2023)
Clare S. Hardman,Yi-Ling Chen,Marcin Wegrecki,Soo Weei Ng, Robert Murren, Davinderpreet Mangat,John-Paul Silva,Rebecca Munro,Win Yan Chan,Victoria O’Dowd,Carl Doyle,Prashant Mori, Andy Popplewell,Jamie Rossjohn,Daniel Lightwood,Graham S. Ogg
ARTHRITIS & RHEUMATOLOGY (2022): 21-22
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iScience (2022)
Journal of Clinical Oncologyno. 16 (2022): 4107-4107
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作者统计
#Papers: 206
#Citation: 11266
H-Index: 51
G-Index: 104
Sociability: 7
Diversity: 3
Activity: 57
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