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Dr. Shen is an experienced researcher in clinical pharmacology, specializing in drug metabolism and pharmacokinetics. He has a particular interest in pharmacokinetic modeling and simulations as an analytical tool. His research has involved collaboration with investigators in several clinical subspecialties, notably epilepsy, anesthesiology and pain. A common theme in these diverse therapeutic areas is the cause of inter-individual variability in drug response; causal factors that Dr. Shen has focused on include drug-drug interactions, genetic polymorphism of drug-metabolizing enzymes, physiologic changes due to childhood development, pregnancy and aging, etc. Dr. Shen had previously collaborated with the PI of this UM1-application, Dr. Rodney Ho on the development of novel lipid-based formulations for spinal delivery of opioid analgesics that were aimed at minimizing their rostral spread within the CSF and restrict its vascular uptake into the systemic circulation. It is fitting that we are now considering another collaboration involving this time the development of long-acting, subcutaneous lipid nanoparticle delivery system for antiretroviral drugs targeted for the HIV sanctuary sites in the lymph nodes. Dr. Shen will lead in 1) the pharmacokinetic design of preclinical and clinical studies, 2) the analysis and interpretation of the pharmacokinetic data, and 3) modeling and simulations to further our understanding on how transit of nanoparticles through the lymphatic system, its release kinetics at the target site, and in vivo stability of the nanoparticles jointly control the sustained therapeutic action of the nano-delivery system, particularly with combination drug loading.
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Journal of pharmaceutical sciences (2024)
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PHARMACEUTICAL RESEARCHno. 11 (2023): 2597-2606
Dennis D. Wang,Sophia E. Airhart,Bo Zhou,Laura M. Shireman, Siyi Jiang, Carolina Melendez Rodriguez, James N. Kirkpatrick,Danny D. Shen,Rong Tian,Kevin D. O’Brien
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