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Inwardly rectifying potassium channels (Kirs) play a critical role in mediating renal K secretion. We have found that basolateral Kcnj10 expression determines the apical Na-Cl cotransporter in distal convoluted tubule (DCT). However, the underlying mechanism remains largely unknown. My research goal is to explore the mechanism of posttranslational regulation of Kirs channels in the non-excitable epithelial cells, such as renal DCT cells, in response to low potassium diet intake. In addition, I have demonstrated that Kcnj10 is a major Kir channel and determines the membrane potential in DCT epithelial cell. Furthermore, my recent work shows that Kir5.1, a co-expressed protein with Kir4.1, mediates nedd4-2-induced ubiquitination of Kir4.1 which in turn to decrease Kir4.1 activity. My current ongoing research interest expands to study the regulation of Kir5.1 in modulating Kir4.1 in response to high Na or high K diets.
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Hypertension (Dallas, Tex. : 1979)no. 1 (2024): 126-137
Adrián R Murillo-de-Ozores,Héctor Carbajal-Contreras, Germán R Magaña-Ávila, Raquel Valdés, Leoneli I Grajeda-Medina,Norma Vázquez,Teresa Zariñán, Alejandro López-Saavedra,Avika Sharma,Dao-Hong Lin,Wen-Hui Wang,Eric Delpire,
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