David Harrison
教授
Department of Pharmacology
School of Medicine, Vanderbilt University;Department of Molecular Physiology and Biophysics, School of Medicine, Vanderbilt University;Division of Clinical Pharmacology, Vanderbilt University Medical Center;Department of Medicine, Vanderbilt University Medical Center
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个人简介
His research laboratory has been focused on understanding how inflammation, and in particular, the adaptive immune response contributes to hypertension. Several years ago, they found that T cells are essential for the development of hypertension. His lab has shown that various hypertensive stimuli, including angiotensin II, norepinephrine and DOCA-salt cause activation of T cells and leads to their accumulation in the perivascular fat and kidneys. The data indicates that T cell-derived cytokines such as IL-17 and TNF-a enhance vasoconstriction and sodium retention, leading to the hypertensive phenotype. Central signals derived from the circumventricular organs contribute to T cell activation, and manipulation of signals from this region affect T cell activation and the eventual elevation in blood pressure caused by angiotensin II.
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论文共 1391 篇作者统计合作学者相似作者
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Hypertension (Dallas, Tex. : 1979)no. 5 (2024): e44-e46
Circulation researchno. 1 (2024): 30-32
Pavlina Spiliopoulou,Farasat Kazmi,Francesca Aroldi, Thomas Holmes, David Thompson, Lucinda Griffiths,Cathy Qi,Matthew Parkes,Simon Lord,Gareth J. Veal,David J. Harrison,Vicky M. Coyle,
Journal of Experimental & Clinical Cancer Researchno. 1 (2024): 1-16
GEROSCIENCEno. 1 (2024): 795-816
Dillum Patel,Alison L. Dickson, Greice M. Zickuhr,In Hwa Um,Oliver J. Read, Clarissa M. Czekster,Peter Mullen,David J. Harrison, Jeniffer Bre
crossref(2024)
D. G. Harrison, M. Bader, L. O. Lerman, G. Fink, S. A. Karumanchi, J. F. Reckelhoff, M. L. S. Sequeira-Lopez, R. M. Touyz
Hypertension (Dallas, Tex. : 1979)no. 1 (2024): 3-5
Journal of the Royal Society of Medicineno. 5 (2023): 1410768231172151-166
Maaike C. Swets,Steven Kerr,James Scott-Brown, Adam B. Brown,Rishi Gupta,Jonathan E. Millar,Enti Spata, Fiona McCurrach,Andrew D. Bretherick,Annemarie Docherty,David Harrison,Kathy Rowan,
Nature communicationsno. 1 (2023): 7374-10
Nutrition, metabolism, and cardiovascular diseases : NMCDno. 7 (2023): 1398-1406
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