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个人简介
In recent years at Salk, Schubert and his wife, Senior Staff Scientist Pamela Maher, developed a novel screening technique to test for naturally occurring chemicals that can prevent the type of nerve cell death found in neurodegenerative diseases. This led to the establishment of the first medicinal chemistry lab at Salk where he worked to make derivatives of the neuroprotective natural products that have much improved medicinal, chemical and pharmacological properties over the parent compounds. For example, the lab found that fisetin, which naturally occurs in strawberries, prevents memory and learning deficits in mouse models of Parkinson’s and Alzheimer’s diseases. A synthetic derivative of fisetin is now undergoing the studies necessary for moving into clinical trials. Additionally, they found that a synthetic derivative of the curry spice curcumin, called J147, improves behavioral and pathological symptoms associated with Alzheimer’s, traumatic brain injury and stroke. This compound is currently in a phase 1 clinical trial for the treatment of Alzheimer’s.
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论文共 168 篇作者统计合作学者相似作者
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Agingno. 6 (2024): 4980-4999
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCESno. 7 (2023)
Free radical biology & medicine (2022): 33-51
Nihon Yakuri Gakkai nenkai yoshishuno. 0 (2020): 3-269
Devin Kepchia,Ling Huang,Richard Dargusch, Robert A. Rissman,Maxim N. Shokhirev,Wolfgang Fischer,David Schubert
Figshare (2020)
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作者统计
#Papers: 168
#Citation: 20065
H-Index: 63
G-Index: 141
Sociability: 6
Diversity: 0
Activity: 1
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