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The gut microbiota is emerging as an important modulator of brain function and behavior, as several recent discoveries reveal substantial effects of the microbiome on neurophysiology, neurogenesis, blood brain barrier permeability, neuroimmunity, brain gene expression and animal behavior. Despite these findings supporting a “microbiome-gut-brain axis”, the molecular and cellular mechanisms that underlie interactions between the gut microbiota and brain remain poorly understood. To uncover these, the Hsiao laboratory is mining the human microbiota for microbial modulators of host neuroactive molecules, investigating the impact of microbiota-immune system interactions on neurodevelopment and examining the microbiome as an interface between gene-environment interactions in neurological diseases. We aim to dissect biological circuits for communication between the gut microbiota and nervous system, toward understanding fundamental biological pathways that influence brain and behavior. Situated at the interface of neurobiology, immunology and microbiology, we are using integrative systems approaches to study fundamental questions in biology: What are the effects of the microbiota on the nervous system? How do resident microbes communicate with the nervous system? Which individual species or communities confer particular functional effects? How do microbe-nervous system interactions impact health and disease? What, if any, are the potential evolutionary benefits for microbes to interact with the nervous system? Can rational modification of the microbiota be used to treat symptoms of neurological diseases?
The gut microbiota is emerging as an important modulator of brain function and behavior, as several recent discoveries reveal substantial effects of the microbiome on neurophysiology, neurogenesis, blood brain barrier permeability, neuroimmunity, brain gene expression and animal behavior. Despite these findings supporting a “microbiome-gut-brain axis”, the molecular and cellular mechanisms that underlie interactions between the gut microbiota and brain remain poorly understood. To uncover these, the Hsiao laboratory is mining the human microbiota for microbial modulators of host neuroactive molecules, investigating the impact of microbiota-immune system interactions on neurodevelopment and examining the microbiome as an interface between gene-environment interactions in neurological diseases. We aim to dissect biological circuits for communication between the gut microbiota and nervous system, toward understanding fundamental biological pathways that influence brain and behavior. Situated at the interface of neurobiology, immunology and microbiology, we are using integrative systems approaches to study fundamental questions in biology: What are the effects of the microbiota on the nervous system? How do resident microbes communicate with the nervous system? Which individual species or communities confer particular functional effects? How do microbe-nervous system interactions impact health and disease? What, if any, are the potential evolutionary benefits for microbes to interact with the nervous system? Can rational modification of the microbiota be used to treat symptoms of neurological diseases?
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Elena Coley,Gregory Lum,Geoffrey Pronovost,Ezgi Ozcan,Kristie Yu,Janet Mcdermott, Anna chakhoyan, Eliza Goldman,Helen Vuong,Jorge Paramo,Alison Chu,Kara Calkins,
biorxiv(2024)
Kristie B Yu,Celine Son, Anisha Chandra,Jorge Paramo, Anna Novoselov,Ezgi Özcan, Sabeen A Kazmi,Gregory R Lum, Arlene Lopez-Romero,Jonathan B Lynch,Elaine Y Hsiao
bioRxiv : the preprint server for biology (2024)
Kelly G Jameson,Sabeen A Kazmi,Celine Son, Donya Mazdeyasnan, Emma Leshan,Helen E Vuong,Jorge Paramo, Arlene Lopez-Romero, Long Yang,Felix E Schweizer,Elaine Y Hsiao
bioRxiv : the preprint server for biology (2023)
Geoffrey N Pronovost, Sahil S Telang, Angela S Chen,Elena J L Coley,Helen E Vuong,Drake W Williams,Kristie B Yu,Tomiko K Rendon,Jorge Paramo, Reuben H Kim,Elaine Y Hsiao
CELL REPORTSno. 12 (2023): 113521-113521
ANNALS OF THE NEW YORK ACADEMY OF SCIENCESno. 1 (2023): 10-16
Elena Coley, Anna Chakhoyan, Geoffrey Pronovost,Janet McDermott, Eliza Goldman,Helen Vuong,Jorge Paramo,Elaine Hsiao
Biological Psychiatryno. 9 (2023): S22
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