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I undertook my PhD at the University of Leeds from 1999-2002 studing recombinant mycobacterial cancer vaccines and their interaction with dendritic cells and lymphocytes under the supervision of Dr Andrew Jackson and Professor Peter Selby. I then moved to the University of Manchester in 2002 where I began work as a postdoctoral research associate in the group of Professor Robert Hawkins and Dr David Gilham. My work focused on the generation and testing of chimeric antigen receptor (CAR) T-cells targeting CD19 for use in the treatment of B-cell malignancies. This work led to an ongoing Kay Kendall Leukaemia funded Phase I clinical trial testing CD19 CAR T-cells in B-cell lymphoma. In 2009 I joined the Targeted Therapy group led by Professor Tim Illidge and my research has focused on investigating the mechanisms of action of type I and type II anti-CD20 antibodies and improving their efficacy in B-cell malignancies through the use of immunomodulatory agents to enhance adaptive immune responses.
研究兴趣
论文共 35 篇作者统计合作学者相似作者
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Ester Fagnano, Swati Pendharkar, Madyson Colton, Philip N. Jones, Marta Crespi Sallan,Tetyana Klymenko,Andrejs Braun,Christian Klein,Jamie Honeychurch,Eleanor J. Cheadle,Timothy M. Illidge
Frontiers in Cell and Developmental Biology (2023): 1270398-1270398
Radiation Oncologyno. 1 (2020): 1-11
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