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个人简介
The Jorgensen laboratory is identifying the proteins that function at the synapse to release and recycle synaptic vesicles. To identify these molecules, we have undertaken a genetic analysis of neurotransmission in the nematode Caenorhabditis elegans. C. elegans is particularly advantageous for such studies for several reasons: First, mutants with defective synapses are viable and can be studied as adults. Second, we can select for mutants with defective neurotransmission using drug resistance screens. Third, we can characterize mutant synapses at the ultrastructural and electrophysiological levels. So far the lab has identified over 30 genes that are required for normal synaptic transmission. Some of these genes are required for synaptic vesicle exocytosis and some are required for synaptic vesicle endocytosis. The precise function of these proteins is being determined using electophysiological, biochemical, fluorescence and electron microscopic techniques.
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Mandy Koopman,Lale Güngördü,Leen Janssen,Renée I. Seinstra,Janet E. Richmond, Nathan Okerlund, René Wardenaar,Priota Islam,Andre E.X. Brown,Erik M. Jorgensen,Ellen A.A. Nollen
Cell Reportsno. 5 (2024): 114204-114204
E. Nicholas Petersen,Mahmud Arif Pavel,Samuel S. Hansen, Manasa Gudheti,Hao Wang,Zixuan Yuan,Keith R. Murphy,William Ja,Heather A. Ferris,Erik Jorgensen,Scott B. Hansen
ELIFE (2024)
Sanduni I. Fernando, Jason T. Martineau,M. Wayne Davis, Andrew R. Erickson, Benjamin C. Bromley,Erik M. Jorgensen,Jordan M. Gerton
Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXXI (2024)
Advances in neurobiology (2023): 63-118
Y. Imoto,S. Raychaudhuri, Y. Ma,P. Fenske,E. Sandoval,K. Itoh,E. Blumrich, H. T. Matsubayashi,L. Mamer,F. Zarebidaki, B. Soehl-Kielczynski,T. Trimbuch,
Optics expressno. 20 (2023): 33565-33581
microPublication biology (2022)
Microscopy and Microanalysisno. S1 (2022): 1564-1566
Sanduni Fernando, Jason Martineau,Thien N Vu,Brian Baker, Rob J. Hobson,Brian Mueller,Rajesh Menon,Erik M. Jørgensen,Jordan M. Gerton
bioRxiv (Cold Spring Harbor Laboratory) (2022)
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