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Our goals are to understand sodium-glucose cotransporters (SGLTs) from the atomic level to their physiological roles in humans. These transporters (SGLTs) are responsible for the active transport of glucose into cells and glucose sensing in the body. We study the structure and function of human and bacterial SGLTs using a combination of biophysical, biochemical, molecular dynamic, and genetic techniques to unravel how these molecular machines convert the energy stored in sodium gradients to drive the uphill transport of solutes. The SGLTs are expressed Escherichia coli, cultured cell lines and Xenopus laevis oocytes for biophysical studies or for the isolation of protein for biochemical and structural determinations in collaboration with the Abramson laboratory. We are also interested in how mutations in SGLT genes cause defects in intestinal and renal glucose transport, i.e., Glucose Galactose Malabsorption and Familial Renal Glucosuria.
The SGLT genes are expressed not only in the intestine and kidney but throughout the body, including brain. To explore their function, we have developed, in collaboration with the Barrio group, methods to image SGLTs in animal and human subjects using Positron Emission Tomography (PET). By studying SGLT knockout mice, healthy human subjects, patients with inherited disorders and cancers we are working to parse out the function of the SGLTs throughout the body. Specifically, we study how SGLT inhibitors can be used to treat patients with diabetes and cancer.
Our goals are to understand sodium-glucose cotransporters (SGLTs) from the atomic level to their physiological roles in humans. These transporters (SGLTs) are responsible for the active transport of glucose into cells and glucose sensing in the body. We study the structure and function of human and bacterial SGLTs using a combination of biophysical, biochemical, molecular dynamic, and genetic techniques to unravel how these molecular machines convert the energy stored in sodium gradients to drive the uphill transport of solutes. The SGLTs are expressed Escherichia coli, cultured cell lines and Xenopus laevis oocytes for biophysical studies or for the isolation of protein for biochemical and structural determinations in collaboration with the Abramson laboratory. We are also interested in how mutations in SGLT genes cause defects in intestinal and renal glucose transport, i.e., Glucose Galactose Malabsorption and Familial Renal Glucosuria.
The SGLT genes are expressed not only in the intestine and kidney but throughout the body, including brain. To explore their function, we have developed, in collaboration with the Barrio group, methods to image SGLTs in animal and human subjects using Positron Emission Tomography (PET). By studying SGLT knockout mice, healthy human subjects, patients with inherited disorders and cancers we are working to parse out the function of the SGLTs throughout the body. Specifically, we study how SGLT inhibitors can be used to treat patients with diabetes and cancer.
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论文共 253 篇作者统计合作学者相似作者
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Nature communicationsno. 1 (2023): 1-12
FUNCTIONno. 5 (2021): zqab048-zqab048
KIDNEY360no. 12 (2021): 2027-2037
FUNCTIONno. 5 (2021)
FUNCTIONno. 1 (2021)
Studies of Epithelial Transporters and Ion ChannelsPhysiology in Health and Diseasepp.211-254, (2020)
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