基本信息
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Career Trajectory
Bio
Fidel-Nicolás Lolo graduated in Biology at the Universidad de Alcalá de Henares (UAH, Madrid) in 2006 and then did a master at the same University on cellular signalling in 2007. During his PhD thesis, he studied cell competition and its relation to cancer using Drosophila melanogaster as a model organism (Development 2009) at the international environment of CNIO (one of the best cancer research centres on a global scale). Particularly, he worked on engulfment and haemocytes (Drosophila macrophages) showing their implication in the elimination of “loser” cells during cell competition (Cell Reports 2012 and Bioessays 2013). He extended this previous work and showed that loser cells secrete the translation-related enzyme AatsTyr, and finally demonstrated its participation in haemocytes recruitment during cell competition (Nature Comm. 2015). He also had the opportunity to participate in the study of myc and mouse macrophages and its role in macrophage maturation and pro-tumoral activities (Plos One 2012 and Bio Open 2017). To investigate all these processes, he applied different cell biology and molecular biology techniques both in vitro (with S2 Drosophila cells) and in adult tissues.
Now, he works as a postdoctoral researcher in the laboratory of Miguel Ángel del Pozo at CNIC (a world leading centre in cardiovascular research). He studies the role of caveolae, omega-shaped invaginations of the plasma membrane, in the field of mechanobiology, using biophysical techniques such as Magnetic Tweezers, Atomic force Microscopy, Traction Force Microscopy or Optical Tweezers, in collaboration with different groups here in Spain (Pere Roca Cusachs, Xavier Trepat and Daniel Navajas in Barcelona), and also in France (Christophe Lamaze in Paris), Germany (Jochen Guck in Dresden, and Britta Qualmann in Jena) and in Canada (Robert I. Nabi in Vancouver). His aim is to identify new mechanosensing and mechanotransducer elements within caveaole to better understand their implication both in physiology and diseases such as cancer and atherosclerosis. His current work is now part of two papers (Lolo et al., “Caveolae couple mechanical stress to integrin recycling and activation” eLife: 10.7554/eLife.82348, and Lolo et al., “Caveolin-1 dolines form a distinct and rapid caveolae-independent mechanoadaptation system" NCB: 10.1038/s41556-022-01034-3).
Research Interests
Papers共 14 篇Author StatisticsCo-AuthorSimilar Experts
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bioRxiv (2023)
Fidel-Nicolas Lolo,Nikhil Walani,Eric Seemann,Dobryna Zalvidea,Dacil Maria Pavon,Gheorghe Cojoc,Moreno Zamai,Christine Viaris de Lesegno,Fernando Martinez de Benito,Miguel Sanchez-Alvarez,Juan Jose Uriarte,Asier Echarri,Daniel Jimenez-Carretero,Joan-Carles Escolano,Susana A. Sanchez,Valeria R. Caiolfa,Daniel Navajas,Xavier Trepat,Jochen Guck,Christophe Lamaze,Pere Roca-Cusachs,Michael M. Kessels,Britta Qualmann,Marino Arroyo,Miguel A. Del Pozo
Cancer and Metastasis Reviewsno. 2 (2020): 485-503
Nature Communicationsno. 1 (2015)
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Author Statistics
#Papers: 14
#Citation: 310
H-Index: 9
G-Index: 13
Sociability: 4
Diversity: 2
Activity: 36
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