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Visual perception begins when a photon is captured by an opsin pigment in a rod or cone cell. This causes photoisomerization of the retinaldehyde chromophore from 11cRAL to atRAL, converting opsin to its signaling state. Shortly after, the active opsin decays, releasing free atRAL. Sensitivity is only restored to the resulting apo-opsin when it combines with another 11cRAL to form a new pigment. Our laboratory is interested in the biochemical processes that convert atRAL back to 11cRAL. The genes for several proteins of the visual cycle are affected in human inherited retinal and macular degenerations. We are working to understand what these proteins normally do for a living, and how loss of function causes blindness in people with disease-causing mutations. We are also interested in how the visual opsins maintain light sensitivity under daylight conditions where the photon fluxes and hence chromophore-consumption rates are millions-fold higher than at night. We have discovered several processes that are hugely stimulated by visible light. The action spectra for these light-induced molecular events provides interesting clues. We have several exciting projects open to study how natural light exposure affects the dynamics of visual retinoids. Our lab employs a wide range of methodologies and makes extensive use of genetically modified mice.
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Reference Module in Neuroscience and Biobehavioral Psychology (2024)
Joanna J. Kaylor,Rikard Frederiksen, Christina K. Bedrosian, Melody Huang, David Stennis-Weatherspoon, Theodore Huynh, Tiffany Ngan, Varsha Mulamreddy,Alapakkam P. Sampath,Gordon L. Fain,Gabriel H. Travis
CURRENT BIOLOGYno. 15 (2024)
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#Papers: 111
#Citation: 7796
H-Index: 39
G-Index: 88
Sociability: 6
Diversity: 0
Activity: 0
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