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Our overall goal is to characterize the cell signaling pathways that inhibit the uncontrolled growth of epithelial-derived tumor cells, the cell type of most human cancers and develop preclinical strategies that can potentially be used to design new anti-cancer therapeutics. Molecular, biochemical, cell biological and physiological experimental strategies are being utilized to explore the mechanisms by which extracellular signals (such as steroid hormones, growth factors and certain dietary and nondietary phytochemicals) coordinately regulate the proliferation, apoptosis, cell migration and cell-cell interactions of human cancer cells. We employ several distinct human cancer cell model systems that include hormone sensitive and insensitive breast cancer cells, prostate cancer cells, endometrial cancer cells, and human melanoma cells. In addition, we have been involved in a clinical collaboration, and we have recently established that certain human mammary epithelial cancer cells can be converted into a phenotype with stem cell-like properties that becomes highly sensitive to the apoptotic effects of dietary indoles. The breadth of the cancer research strategies in the Firestone lab spans the range from “promoter bashing” and intracelluar signaling to physiological approaches with animal tumor models and human clinical studies.
Our overall goal is to characterize the cell signaling pathways that inhibit the uncontrolled growth of epithelial-derived tumor cells, the cell type of most human cancers and develop preclinical strategies that can potentially be used to design new anti-cancer therapeutics. Molecular, biochemical, cell biological and physiological experimental strategies are being utilized to explore the mechanisms by which extracellular signals (such as steroid hormones, growth factors and certain dietary and nondietary phytochemicals) coordinately regulate the proliferation, apoptosis, cell migration and cell-cell interactions of human cancer cells. We employ several distinct human cancer cell model systems that include hormone sensitive and insensitive breast cancer cells, prostate cancer cells, endometrial cancer cells, and human melanoma cells. In addition, we have been involved in a clinical collaboration, and we have recently established that certain human mammary epithelial cancer cells can be converted into a phenotype with stem cell-like properties that becomes highly sensitive to the apoptotic effects of dietary indoles. The breadth of the cancer research strategies in the Firestone lab spans the range from “promoter bashing” and intracelluar signaling to physiological approaches with animal tumor models and human clinical studies.
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Natural Products for Cancer Chemopreventionpp.489-516, (2020)
ANTI-CANCER DRUGSno. 9.0 (2017): 1018-1031
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