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Sugars are abundant components of diet and are essential for supplying our metabolic needs. Sucrose from our food is broken down in the intestine to produce both glucose and fructose. These sugars are absorbed into the blood stream and act as a supply of nutrient for tissue metabolism. Sugar disposal occurs via uptake into selective tissues that utilise specialised membrane tranporters or GLUTs. Recent genome analysis has indicated that the GLUT family of proteins includes some new un-characterised isoforms. There are now known to be 13 mammalian GLUTs which have a range of substrate preference and tissue distributions. Some of the GLUT proteins transport glucose in preference to fructose while others preferentially transport fructose and some rarer sugars.Our research interests include an investigation of the substrate preferences of the transporter proteins. This involves utilisation of chemical biology approaches for the design and chemical synthesis of sugar analogues and inhibitors of the GLUT proteins. Anormal disposal and utilisation of sugars gives rise to diseases that include obesity and type 2 diabetes.
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Shawna L McMillin, Parker L Evans, William M Taylor,Luke A Weyrauch, Tyler J Sermersheim,Steven S Welc,Monique R Heitmeier,Richard C Hresko,Paul W Hruz,Francoise Koumanov,Geoffrey D Holman,E Dale Abel,
Pflugers Archiv : European journal of physiologyno. 9 (2020): 1155-1175
Zhou Zhou, Franziska Menzel,Tim Benninghoff,Alexandra Chadt, Chen Du,Geoffrey D. Holman,Hadi Al-Hasani
Photoaffinity Labeling for Structural Probing Within Proteinpp.183-196, (2017)
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