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个人简介
Research and Teaching Interests:
Significant advances in the treatment of human cancer and other serious medical problems are becoming increasingly more dependent upon scientists well trained in organic chemistry, biochemistry and biology. Robert Pettit's group is organized to provide the specialized training necessary to undertake problems concerned with the discovery of anticancer substances for the treatment of cancer. Among various activities, they are pursuing a unique program concerned with isolation, structural identification and synthesis of naturally occurring anticancer agents from marine animals, plants, and arthropods. Studies concerned with synthetic methods, and routes to certain important biosynthetic products comprise related areas of interest.
Specific research interests: chemistry of natural products (peptides, nucleotides, and steroids), cancer chemotherapy (anticancer agents from arthropods, marine animals and plants), and total synthesis of natural products.
Selected Publications:
1. "Antineoplastic Agents 560. Isolation and Structure of Kitastatin 1 from an Alaskan Kitasatospora sp.," G.R. Pettit, R. Tan, R.K.Pettit, T.H. Smith, S. Feng, D.L. Doubek, L. Richert, J. Hamblin, C. Weber and J-C. Chapuis,J. Nat. Prod. 70, 1069-1072 (2007).
2. "Antineoplastic Agents 561. Total Synthesis of Respirantin ," G.R. Pettit, T.H. Smith, S. Feng, J.C. Knight, R. Tan, R.K. Pettit and P.A. Hinrichs, J. Nat. Prod. 70, 1073-1083 (2007).
3. "Antineoplastic Agents 550. Synthesis of 10b (S) - epipancratistatin from (+) - Narciclasine," G.R. Pettit, N. Melody, D.L. Herald, J.C. Knight and J-C. Chapuis, J. Nat. Prod. 70, 417(2007).
4. "Comparison of the Activities of the Truncated Halichondrin B Analog NSC 707389 (E7389) with those of the Parent Compound and a Proposed Binding Site on Tubulin," D.A. Dabydeen, J.C. Burnett, R.B. Bai, P. Verdier-Pinard, M.J. Yu, B.A.Littlefield, S.J.H. Hickford, G.R. Pettit, J.W. Blunt, M.H.G. Munro, R. Gussio and E.' Hamel, Molecular Pharmacology 70, 1866 (2006).
5. "Antineoplastic Agents 554. The Manitoba Bacterium Streptomyces sp.," G.R. Pettit, J.Du, R.K. Pettit, L.A. Richert, V. Mukku and M.S. Hoard, J. Nat. Prod 69, 804-806 (2006).
Significant advances in the treatment of human cancer and other serious medical problems are becoming increasingly more dependent upon scientists well trained in organic chemistry, biochemistry and biology. Robert Pettit's group is organized to provide the specialized training necessary to undertake problems concerned with the discovery of anticancer substances for the treatment of cancer. Among various activities, they are pursuing a unique program concerned with isolation, structural identification and synthesis of naturally occurring anticancer agents from marine animals, plants, and arthropods. Studies concerned with synthetic methods, and routes to certain important biosynthetic products comprise related areas of interest.
Specific research interests: chemistry of natural products (peptides, nucleotides, and steroids), cancer chemotherapy (anticancer agents from arthropods, marine animals and plants), and total synthesis of natural products.
Selected Publications:
1. "Antineoplastic Agents 560. Isolation and Structure of Kitastatin 1 from an Alaskan Kitasatospora sp.," G.R. Pettit, R. Tan, R.K.Pettit, T.H. Smith, S. Feng, D.L. Doubek, L. Richert, J. Hamblin, C. Weber and J-C. Chapuis,J. Nat. Prod. 70, 1069-1072 (2007).
2. "Antineoplastic Agents 561. Total Synthesis of Respirantin ," G.R. Pettit, T.H. Smith, S. Feng, J.C. Knight, R. Tan, R.K. Pettit and P.A. Hinrichs, J. Nat. Prod. 70, 1073-1083 (2007).
3. "Antineoplastic Agents 550. Synthesis of 10b (S) - epipancratistatin from (+) - Narciclasine," G.R. Pettit, N. Melody, D.L. Herald, J.C. Knight and J-C. Chapuis, J. Nat. Prod. 70, 417(2007).
4. "Comparison of the Activities of the Truncated Halichondrin B Analog NSC 707389 (E7389) with those of the Parent Compound and a Proposed Binding Site on Tubulin," D.A. Dabydeen, J.C. Burnett, R.B. Bai, P. Verdier-Pinard, M.J. Yu, B.A.Littlefield, S.J.H. Hickford, G.R. Pettit, J.W. Blunt, M.H.G. Munro, R. Gussio and E.' Hamel, Molecular Pharmacology 70, 1866 (2006).
5. "Antineoplastic Agents 554. The Manitoba Bacterium Streptomyces sp.," G.R. Pettit, J.Du, R.K. Pettit, L.A. Richert, V. Mukku and M.S. Hoard, J. Nat. Prod 69, 804-806 (2006).
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