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One major area of research is to study the regulation of immune cells during bacterial infection and identify molecules important in regulating inflammation. We have focused on the function of a novel set of receptors known as Mer/Axl/Tyro3 receptor tyrosine kinases. Mer is expressed on macrophages; however, only recently have possible functions been elucidated. We find that Mer is important in the clearance of apoptotic cells and the failure to do so results in autoimmune disease such as systemic lupus erythematosus. We believe that this process may alter antigen presentation and appears important in the down regulation of inflammation, particularly TLR4-mediated activation of macrophages and dendritic cells.. Furthermore, this receptor may be key to understanding certain heritable forms of retinitis pigmentosum which leads to blindness.
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Diagnostics (Basel, Switzerland)no. 5 (2021): 786
International review of cell and molecular biology (2021): 165-210
Kasey Skinner,Martin Ferris,Ryan Bash, Abigail Shelton, Erin Smithberger, Steve Angus,Brian Golitz,Noah Sciaky,Jeremy Simon,Jason Stein,Glenn Matsushima,Quinn Ostrom,
Journal of immunology (Baltimore, Md. : 1950)no. 1 (2015): 196-206
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