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G.V.Shivashankar is currently a He carried out his PhD at the Rockefeller University (1994-1999) and Postdoctoral research at NEC Research Institute, Princeton USA (1999-2000). He was a tenured faculty at the National Center for Biological Sciences, NCBS-TIFR- Bangalore, India (2000-2009) before relocating to the National University of Singapore (NUS) in 2010. He was the Deputy Director of the Mechanobiology Institute at NUS (2011-2019) and was the IFOM-NUS Chair Professor (2014-2019) before joining ETH. His scientific awards include the Birla Science Prize in 2006 and he was elected to the Indian Academy of Sciences in 2010 and to the EMBO membership in 2019.
Cells within the tissue microenvironment are highly heterogeneous and integrate both, mechanical and biochemical signals to maintain homeostasis. Sustained modulations in such micro-environmental signals result in cell-state transitions including disease states; however, the underlying mechanisms are still unclear. Using a multi-disciplinary approach, including single-cell imaging, functional genomics and machine learning, we study the coupling between cell mechanics and genome organization in regulating cell-state homeostasis and its transitions. Our studies aimed at an in-depth understanding of the mechanical regulation of genome programs have major implications in regenerative medicine and for early disease diagnostics.
Cells within the tissue microenvironment are highly heterogeneous and integrate both, mechanical and biochemical signals to maintain homeostasis. Sustained modulations in such micro-environmental signals result in cell-state transitions including disease states; however, the underlying mechanisms are still unclear. Using a multi-disciplinary approach, including single-cell imaging, functional genomics and machine learning, we study the coupling between cell mechanics and genome organization in regulating cell-state homeostasis and its transitions. Our studies aimed at an in-depth understanding of the mechanical regulation of genome programs have major implications in regenerative medicine and for early disease diagnostics.
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PHYSICAL REVIEW LETTERSno. 5 (2024): 058401-058401
Tina Pekeč,Saradha Venkatachalapathy, Anne R. Shim, Daniel Paysan,Michal Grzmil,Roger Schibli,Martin Béhé,G. V. Shivashankar
Scientific Reportsno. 1 (2023): 1-14
arXiv (Cornell University) (2023)
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CURRENT OPINION IN STRUCTURAL BIOLOGY (2023): 102728-102728
Vaidehi Krishnan, Yu Lin Chong,Tuan Zea Tan,Madhura Kulkarni, Muhammad Bakhait Bin Rahmat, Lavina Sierra Tay, Haresh Sankar, Doorgesh S. Jokhun, Amudha Ganesan,Linda Shyue Huey Chuang,Dominic C. Voon,GV Shivashankar,
crossref(2023)
bioRxiv : the preprint server for biology (2023)
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