Herbert M. Lachman
教授
Department of Psychiatry and Behavioral Sciences
Albert Einstein College of Medicine, Yeshiva University;Department of Medicine, Albert Einstein College of Medicine, Yeshiva University;Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Yeshiva University;Department of Genetics, Albert Einstein College of Medicine, Yeshiva University
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基本信息
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职业迁徙
个人简介
Dr. Herbert Lachman is a physician and behavioral geneticist interested in the molecular and genetic basis of schizophrenia (SZ), autism spectrum disorders (ASD), bipolar disorder (BD), and intellectual and developmental disabilities (IDD). The lab’s primary research projects involve the use of induced pluripotent stem cells (iPSCs) for modeling neuropsychiatric disorders in vitro. Patient-specific iPCS are generated from skin fibroblasts or CD34+ white blood cells, which are ultimately induced to differentiate into neurons, cerebral organoids, and microglia. Epigenetic analysis and gene expression profiling for protein-coding genes, long non-coding RNAs and microRNAs are then carried out. In addition, the lab also studies the effects of some candidate genes of interest on endosome recycling, innate immune phenomena, neurite outgrowth, and, in collaboration with members of the neuroscience department, electrophysiolgical properties of pure cultures of human glutamatergic neurons and GABAergic interneurons.
研究兴趣
论文共 104 篇作者统计合作学者相似作者
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Matanel Yheskel,Hayden A M Hatch,Erika Pedrosa, Bethany K Terry, Aubrey A Siebels, Xiang Yu Zheng,Laura E R Blok,Michaela Fencková,Simone Sidoli,Annette Schenck,Deyou Zheng,Herbert M Lachman,
Janet Lynn Cunningham,Jennifer Frankovich,Robert A Dubin,Erika Pedrosa, Refia Nur Baykara, Noelle C Schlenk, Shahina Maqbool, Hedwig Dolstra, Jacqueline Marino, Jacob Edinger, Julia Shea, Gonzalo Laje,
medrxiv(2024)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Daniel Cole,Zhengrui Xiao,Varun Gupta, Jesus D. Anampa Mesias, Noelle Townsend, Gretchen Mackie, Ami Sanghvi,Rahul Thakur,Herbert Lachman,Irina Murakhovskaya
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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bioRxiv : the preprint server for biology (2023)
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Rosario Trifiletti,Herbert M. Lachman, Olivia Manusama,Deyou Zheng,Alberto Spalice,Pietro Chiurazzi, Allan Schornagel,Andreea M. Serban,Rogier van Wijck, Janet L. Cunningham,Sigrid Swagemakers,Peter J. van der Spek
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