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职业迁徙
个人简介
I have been in the genomics field for over 30 years, developing an extensive expertise in microbial genomics, functional genomics, comparative genomics, and bioinformatics. I have led the genome sequencing and analysis of many organisms, starting with eukaryotic chromosomes then shifting towards bacterial pathogens. I was the lead author on the first published genomes of Neisseria meningitidis, Streptococcus pneumoniae, and Streptococcus agalactiae. In collaboration with the group of Dr. Rino Rappuoli (GlaxoSmithKline, former Chiron Vaccines and Novartis Vaccines and Diagnostics), I pioneered the fields of reverse vaccinology and pangenomics. The former makes use of genomics to identify novel protein candidates for vaccine development. The latter is the characterization of the genome content of an entire species using multiple strains. I have conducted many studies of bacterial diversity and transcriptional profiling using RNA-seq, as well as functional genomics analyses to identify genes essential for virulence in streptococci using Tn-seq. I have also supervised the development of bioinformatics tools to compare closely related bacterial genomes and enhance transcriptomics analyses.
研究兴趣
论文共 169 篇作者统计合作学者相似作者
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Rosangela Salerno-Goncalves, Haiyan Chen, Andrea C. Bafford, Mariana Izquierdo,Juan Carlos Hormazabal,Rosanna Lagos,Herve Tettelin, Adonis D'Mello,Jayaum S. Booth,Alessio Fasano,Myron M. Levine,Marcelo B. Sztein
FRONTIERS IN IMMUNOLOGY (2024): 1334762-1334762
Francesca Benedetti,Emmanuel F. Mongodin,Jonathan H. Badger,Arshi Munawwar, Ashley Cellini,Weirong Yuan,Giovannino Silvestri, Carl N. Kraus,Simone Marini, Chozha V. Rathinam, Marco Salemi,Hervé Tettelin,
Proceedings of the National Academy of Sciences of the United States of Americano. 22 (2023)
Virulenceno. 1 (2023): 2215602
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Mario Alles,Manuja Gunasena, Tauqir Zia, Adonis D'Mello, Saroj Saroj Bhattarai, Will Mulhern, Luke Terry, Trenton Scherger,Saranga Wijeratne, Sachleen Singh,Asela Wijeratne,Dhanuja Kasturiratna,
biorxiv(2023)
biorxiv(2023)
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