基本信息
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职业迁徙
个人简介
Higher Education:
PhD degree in Biomedical Sciences (Specialization in Biochemistry), in October 2002, by the Abel Salazar Institute for the Biomedical Sciences, University of Porto. The thesis: “Dynamics of Transthyretin fibrillogenesis: contribution to therapeutic approaches in Familial Amyloidotic Polyneuropathy” was unanimously approved.
Graduated in Biochemistry (Specialization in applied Biochemistry) 1995, Faculty of Sciences/ Abel Salazar Institute for the Biomedical Sciences, University of Porto (grade 15/20).
Positions:
June 2013 - Present- Principal Investigator (FCT Investigator Program) at IBMC, at the Molecular Neurobiology group (IBMC), I3S, Porto, Portugal
September 2013-present - group leader at IBMC (Modulation in Neurodegenerative disorders -MiND group)
Jan 2013-Dec 2013- Pos-doc fellowship (SFRH/BPD/85986/2012)
Jan 2008 -Dec 2012- Assistant Researcher (Ciência 2007 Program) at IBMC
March 2006- December 2007- Post-doc fellowship (SFRH / BPD / 9416 / 2002) supported by Fundação para a Ciência e Tecnologia (FCT), Ministério da Ciência e do Ensino Superior.
November 2002- February 2006- Post-doc fellowship (SFRH / BPD / 9416 / 2002) supported by Fundação para a Ciência e Tecnologia (FCT).
June 2002- October 2002- BI fellowship (POCTI-PL141903-BI) supported by Fundação para a Ciência e tecnologia (FCT).
June 1998- May 2002- pHD fellowship (PRAXIS XXI/BD/15725/98) supported by Fundação para a Ciência e Tecnologia (FCT), Ministério da Ciência e Tecnologia.
April 96- March 1998- BIC fellowship (FMRH/BIC/1482/95) supported by Junta Nacional de Investigação e Tecnoloógica (JNICT), Ministério da Ciência e Tecnologia.
1995- Erasmus fellowship in Århus, Denmark, supported by Porto University.
Participation in research projects –
2012-2014- “Study of natural and synthetic inhibitors of transthyretin amyloidosis and characterization of their mechanism of action”. Funded by FCT (PTDC/SAU-ORG/116645/2010). Team member. 141.755,00 Euros
2012-2014- “Antibody-directed liposomes for Alzheimer’s disease”. Funded by FCT (PTDC/QUI-BIQ/118076/2010). 140.000,00 Euros
2010-2013- “Design and biological activity of fluorinated peptides on the amyloid beta-peptide aggregation”. Team Member. Funded by FCT (PTDC/QUI BIQ/102827/2008). 116.784,00 Euros.
2007-2010- “Modulation of A-Beta Toxicity by Transthyretin in Alzheimer’s disease”. Principal Investigator (PI). Funded by FCT (PTDC/SAU-NEU/64593/2006). 108.592,00 €
“Therapies in familial amyloidotic polyneuropathy” PIC/IC/82824/2007. Membro de equipa. Financiado pela FCT.
2007-2010- “Polymer carriers for the delivery of biopharmaceutical peptides”. Team member. Funded by FCT (PTDC/BIO/69359/2006).
2005-2008- “Role of Transthyretin in A-Beta toxicity”. Principal Investigator (PI). Funded by FCT (POCTI/SAU-NEU/57761/2004). 86.430,00 €
2004-2007- POCI/SAU-OBS/56929/2004- Team member.
2004-2006- "Assessement of therapies for amyloidosis". Team member. Funded by FCT (POCTI/CBO/44630/2002).
2002-2004- "Search on the molecular basis of neurodegeneration in familial amyloid polyneuropathy". Team member. Funded by FCT (POCTI/NSE/38920/2001).
Prizes
2008- Pulido Valente prize attributed to the work described in the paper “Rita Costa, Frederico Ferreira-da-Silva, Maria J. Saraiva, Isabel Cardoso (2008). Transthyretin protects against A-Beta peptide toxicity by proteolytic cleavage of the peptide: a mechanism sensitive to the Kunitz Protease Inhibitor. PLos One e2899.
2003- Mention of Honour in the “Prémio BIAL 2002”, from BIAL Foundation, with the work “Revisiting Neurodegeneration in Familial Amyloidotic Polyneuropathy: a molecular study approach”. The authors: Prof. Doutora Maria João Saraiva; Doutora Mónica Sousa; Doutor António Guimarães; Doutora Isabel cardoso; Doutor Rui Fernandes.
Grant reviewer
2009-present- for the Alzheimer Association grant program since 2009
Paper review:
Reviewer of several papers in international scientific periodicals with referees
Participation in Juries:
- PhD thesis: , 30 July 2013, Valencia, Spain
- Master Thesis: “Mutações no gene da 21-hidroxilase e sua correlação fenotípica”- from Ana Filipa Quintela Vieira – 20 th July 2009
- Master Thesis
Supervisions/ Students
February 2010- present- supervision of Carlos Ribeiro, PhD student, in course.
March 2008- 2009- supervisor of Carlos Ribeiro, master student.
2008-2011- supervision of Ana Rita Leitão Valente Costa, PhD student. Concluded.
2006: supervision of Adriana Gonçalves (BI fellow):
2004-2005: Supervision of Marina Brito, Biochemistry student, Coimbra University.
2003: Supervision of the undergraduate summer school student Margot Fair
研究兴趣
论文共 128 篇作者统计合作学者相似作者
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引用量
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期刊级别
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Journal of the neurological sciences (2023): 121451-121451
bioRxiv (Cold Spring Harbor Laboratory) (2023)
IBRO neuroscience reports (2023): S491-S492
IBRO Neuroscience Reports (2023): S415-S416
Journal of the Neurological Sciences (2023): 121451
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作者统计
#Papers: 128
#Citation: 3475
H-Index: 34
G-Index: 57
Sociability: 6
Diversity: 3
Activity: 43
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