基本信息
浏览量:100
职业迁徙
个人简介
Research Interests
Light-activated tissue repair
Photochemical Tissue Bonding or PTB is a light-activated method for tissue repair in which a photoactive dye is applied to tissue surfaces and irradiation with visible light induces covalent crosslinking of proteins across the surfaces. The “nanosutures” thus formed create an immediate water-tight seal in a non-thermal process. PTB has distinct advantages over conventional sutures, staples and glues and is suitable for wide variety of surgical applications, including sealing corneal and skin incisions and reconnecting peripheral nerves, blood vessels and tendons. A pilot clinical study comparing PTB and traditional sutures for closure of skin excisional wounds has shown the process to be safe and to cause less scarring than sutured closure.
UV-induced oxidative stress
Reactive oxygen species (ROS) are produced in skin that is exposed to solar UV radiation and contribute to acute effects (inflammation) and chronic damage (photoaging and photocarcinogenesis). ROS are also produced in cells by certain dyes after absorbing visible light (photosensitization), a process that is used therapeutically. The Kochevar lab has focused on understanding the basic photochemical and photobiologic mechanisms by which ROS are formed in cells after UV or photosensitization, and by which ROS stimulate specific responses in cells. The goals of these studies are to reduce the damaging effects of ROS on skin and to enhance the therapeutic applications of ROS.
研究兴趣
论文共 188 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn