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Role of ER stress in inflammation
The ER stress pathway allows the cell to adapt to stimuli that alter the protein folding capacity of the ER. Under homeostatic conditions this pathway may subtly modulate ER function. Stimuli that induce differentiation or physiological and infectious insults can induce acute changes in the ER stress signalling response. Defects in the ER stress pathway or potent ER stress signals may alter the balance between between the cell survival and pro-apoptotic pathways evoked during this response.
Role of the integrated Stress response in the atherosclerotic plaque and myocardial infarction
ER stress pathways instigated in macrophages as a result of cholesterol loading or mechanical forces play an important role in the development of the atherosclerosis plaque and aneurysm. I am currently investigating in collaboration with Ziad Mallat (Division of Cardiovascular medicine) how modulation of stress pathways may modify the induction of apoptosis and differentiation in critical cells subsets in disease development.
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