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职业迁徙
个人简介
My research focuses on evolutionary genetics, morphology, the genetics of complex traits and diseases in model organisms, and primate and mammalian evolution. Our studies of complex traits have been performed in non-human primates and in mice, as a model organism. We have studied a variety of traits, including cranial and skeletal morphology, obesity, diabetes, growth, brain morphology, congenital heart disease, scarless wound healing, arthritis, osteoporosis, and knee cartilage regeneration. In these studies we have documented that the effects of genes depend critically on their context, such as environment (high fat diet), sex, and alleles at other loci (epistasis). In general, genes do not have effects on their own but only in a complex web of specific genetic and environmental contexts. This work also aims to identify the genetic elements and nucleotide changes responsible for complex trait variation.
研究兴趣
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Fernando Andrade, Lisa Howell, Christopher J Percival,Joan T Richtsmeier,Ralph S Marcucio,Benedikt Hallgrímsson,James M Cheverud
Geneticsno. 4 (2024)
EVOLVABILITY: A Unifying Concept in Evolutionary Biology?pp.171-198, (2023)
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Jay Devine,Marta Vidal-García,Wei Liu, Amanda Neves,Lucas D. Lo Vercio,Rebecca M. Green,Heather A. Richbourg,Marta Marchini,Colton M. Unger, Audrey C. Nickle,Bethany Radford,Nathan M. Young,
Alex Hubbe,Fabio A. Machado,Diogo Melo,Guilherme Garcia, Harley Sebastião,Arthur Porto,James Cheverud,Gabriel Marroig
biorxiv(2022)
biorxiv(2021)
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