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Monod and Jacob became famous for their work on the E. coli lac operon, which encodes proteins necessary for the transport and breakdown of the sugar lactose (lac). From their own work and the work of others, they came up with a model for how the levels of some proteins in a cell are controlled. In their model, the manufacture of proteins, such as the ones encoded within the lac (lactose) operon, is prevented when a repressor, encoded by a regulatory gene, binds to its operator, a specific site in the DNA sequence that is close to the genes encoding the proteins. (It is now known that a repressor bound to an operator physically blocks RNA polymerase from binding to the promoter, the site where transcription of the adjacent genes begins.)
Study of the control of expression of genes in the lac operon provided the first example of a system for the regulation of transcription. Monod also suggested the existence of messenger RNA molecules that link the information encoded in DNA and proteins. For these contributions he is widely regarded as one of the founders of molecular biology.
Study of the control of expression of genes in the lac operon provided the first example of a system for the regulation of transcription. Monod also suggested the existence of messenger RNA molecules that link the information encoded in DNA and proteins. For these contributions he is widely regarded as one of the founders of molecular biology.
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论文共 37 篇作者统计合作学者相似作者
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Novartis Foundation SymposiaCiba Foundation Symposium - Control Processes in Multicellular Organismspp.3-20, (2008)
Symposium Jacques Monod, Yesterday Molecular Biology, Today,Jacques Monod, Ernesto Quagliariello,Giorgio Bernardi,Agnes Ullmann
mag(1987)
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Biochimica et Biophysica Acta (1978): 205-219
Selected Papers in Molecular Biology by Jacques Monodpp.491-503, (1978)
Selected Papers in Molecular Biology by Jacques Monodpp.335-363, (1978)
Selected Papers in Molecular Biology by Jacques Monodpp.472-490, (1978)
JACQUES MONOD, ANNE-MARIE TORRIANI
Selected Papers in Molecular Biology by Jacques Monodpp.163-175, (1978)
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