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Dr. Manley's laboratory studies several aspects of gene expression, principally in human cells. These include transcription of mRNA encoding genes, and splicing and polyadenylation of the resultant mRNA precursors. These processes all occur in the cell nucleus and require numerous protein (and in the case of splicing, RNA) factors that assemble into massive multi-subunit complexes. Important goals are to understand how these molecules act to regulate gene expression and how they themselves are controlled, and to understand how these processes contribute to cell growth and development, and to disease when dysregulated. These studies involve a large number of experimental approaches, including a variety of in vitro assays, biochemical fractionation and protein purification, structural analyses, genetic studies using a variety of gene targeting approaches in yeast and mammalian cells, and analysis of gene expression in human cell lines and pathological samples.
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论文共 13 篇作者统计合作学者相似作者
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CELL REPORTSno. 3 (2024): 113886-113886
Genes & Developmentno. 1-2 (2023): 41-42
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Proceedings of the National Academy of Sciences of the United States of Americano. 7 (2017): E1419-E1428
Jian Zhang,Yen K. Lieu,Abdullah M. Ali, Alex Penson, Kathryn S. Reggio,Raul Rabadan,Azra Raza,Siddhartha Mukherjee,James L. Manley
mag(2001)
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