James Broach
Distinguished Professor
Department of Biochemistry and Molecular Biology
College of Medicine, The Pennsylvania State University;Department of Otolaryngology - Head and Neck Surgery, The Pennsylvania State University;Penn State Cancer Institute, The Pennsylvania State University;Penn State Institute for Personalized Medicine, Princeton University
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基本信息
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个人简介
The Dr. James Broach lab has studied a variety of biological processes using the yeast Saccharomyces as a model system. These studies have focused primarily on the interaction of cells with their environment, exploring the nature of signaling pathways that cells use to perceive their nutritional state - such as the Ras/protein kinase A pathway and the Target of Rapamycin Complex – and the transcriptional and metabolic responses of those cells to changes in nutritional state. More recently, the lab has focused on the cell’s stress response, using single cell imaging and genome sequencing-based studies of chromatin structure and transcriptional remodeling. These studies yielded the remarkable finding that genetically identical cells in the same environment mount quite different responses to an applied stress, allowing the population as a whole to hedge its bets regarding the best survival strategy in the face of an uncertain future.
研究兴趣
论文共 205 篇作者统计合作学者相似作者
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCESno. 7 (2024): 3785
Marcelo RS Briones, Joao H Campos,Renata C Ferreira,Lisa Schneper, Ilda M Santos,Fernando Antoneli, NYCG ALS Consortium,James R Broach
crossref(2024)
Tarik J. Salameh, Katharine Roth, Lisa Schultz, Zhexi Ma,Anthony S. Bonavia,James R. Broach, Bin Hu,Judie A. Howrylak
Gut Pathogensno. 1 (2023): 1-9
Laura Budurlean, Bing He,Yali Ding,Diwakar Bastihalli Tukaramrao, Chingakham Singh,Joseph Schramm,Daniel Bogush,James Broach,Sinisa Dovat
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTIONno. 12 (2023)
FERMENTATION-BASELno. 2 (2023): 195-195
Clinical infectious diseases : an official publication of the Infectious Diseases Society of Americano. 5 (2023): 768-775
Journal of neural engineeringno. 3 (2023): 036033-036033
Danielle Smith, Kristen Bastug,Kathy Burgoine,James R Broach,Christine Hehnly,Sarah U Morton,Marwan Osman,Steven J Schiff,Jessica E Ericson
medRxiv (Cold Spring Harbor Laboratory) (2023)
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