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个人简介
Our research is focused on the study of coronavirus-host cell receptor interactions, and the role played by glycosyltransferases in protein folding and subcellular targeting. In all cases, we take a structural approach involving x-ray crystallography and electron cryo-microscopy (Cryo-EM). We are currently working on SARS-CoV-2 and the seasonal coronaviruses that cause common cold-like symptoms. By studying the coronavirus Spike protein in complex with receptors and neutralizing antibodies, we seek to understand the basis for viral neutralization, immune evasion, and cross-species transmission. The work is also contributing to the development of antibody therapeutics and vaccines against SARS-CoV-2.
Our most recent work in the glycosyltransferase area deals with the protein-O-glycosyltransferases specific for the EGF-like domains found primarily in the Notch receptor and its ligands. It is not only uncovering how these enzymes ensure the proper folding and targeting of these important signalling molecules but the likely role that they played in the evolution of multicellular organisms. Our interest in glycosyltransferases also extends to those that modify N-glycans to mediate ER protein folding and lysosomal enzyme targeting, processes that are critical in protein homeostasis.
Our most recent work in the glycosyltransferase area deals with the protein-O-glycosyltransferases specific for the EGF-like domains found primarily in the Notch receptor and its ligands. It is not only uncovering how these enzymes ensure the proper folding and targeting of these important signalling molecules but the likely role that they played in the evolution of multicellular organisms. Our interest in glycosyltransferases also extends to those that modify N-glycans to mediate ER protein folding and lysosomal enzyme targeting, processes that are critical in protein homeostasis.
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论文共 97 篇作者统计合作学者相似作者
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Peter Zhou, Jacqueline Watt,Juntao Mai,Huibi Cao,Zhijie Li,Ziyan Chen,Rongqi Duan, Ying Quan,Anne-Claude Gingras,James M Rini,Jim Hu,Jun Liu
Frontiers in immunology (2024): 1430928-1430928
Marie-Ming Aynaud,Lauren Caldwell,Khalid Al-Zahrani,Seda Barutcu,Kin Chan, Andreea Obersterescu, Abiodun Ogunjimi, Min Jin,Kathleen-Rose Zakoor, Shyam Patel, Ron padilla,Mark Jen, Princess Mae, Nusrin Dewsi, Filiam Yonathan, Lucy Zhang, Amelia Ayson-Fortunato, Analiza Aquino,Paul Krzyzanowski,Jared T Simpson,John Bartlett,Ilinca Lungu,Susan Poutanen,Bradly Wouters, Micheal Gekas,James Rini,Laurence Pelletier,Tony Mazzulli,Jeffrey L Wrana
medrxiv(2024)
Camille Merhi, Anna C. Sullivan, Vaidehi T. Bhavaraju, Jamie M. Walker, Kevin F. Beiniek, Samy M. Abdullah,Arash Salardini,James Rini, Alicia Parker
NEUROLOGYno. 17 (2023)
Sabryna Nantel,Salma Sheikh-Mohamed,Gary Y. C. Chao,Alexandra Kurtesi,Queenie Hu,Heidi Wood,Karen Colwill,Zhijie Li, Ying Liu,Laurie Seifried,Benoite Bourdin,Allison McGeer,William R. Hardy,Olga L. Rojas, Tho-Alfakar Al-Aubodah, Zhiyang Liu,Mario A. Ostrowski,Mark A. Brockman,Ciriaco A. Piccirillo,Caroline Quach,James M. Rini,Anne -Claude Gingras,Helene Decaluwe,Jennifer L. Gommerman
medRxiv (Cold Spring Harbor Laboratory) (2023)
Clinical Immunology (2023): 109246-109246
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Salma Sheikh-Mohamed,Gary Chao,Baweleta Isho,Michelle Zuo,Carmit Cohen,Yaniv Lustig,Georgie Nahass,Rachel E. Salomon,Grace Blacker,Mahya Fazel-Zarandi,Bhavisha Rathod,Karen Colwill,Alainna J. Jamal,Zhijie Li,Keelia Quinn Delaunay,Alyson Takaoka,Julia Garnham-Takaoka, Anjali Patel,Christine Fahim,Aimee Patterson,Angel Liu,Nazrana Haq,Shiva Barati,Lois Gilbert,Karen Green,Mohammad Mozafarihashjin,Phillip Samaan,Patrick Budylowski,Walter Siqueira,Samira Mubareka,Mario Ostrowski,James Rini,Olga Rojas,Irving L. Weissman,Michal Caspi Tal,Alison McGeer,Gili Regev,Sharon Straus,Anne-Claude Gingras,Jennifer L. Gommerman
Mucosal Immunologyno. 5 (2022): 799-808
JOURNAL OF LIPID RESEARCHno. 9 (2022): 100256-100256
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作者统计
#Papers: 98
#Citation: 8723
H-Index: 36
G-Index: 67
Sociability: 6
Diversity: 3
Activity: 34
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