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Research Interests
The research in my lab focuses on the development and applications of modern computational methods to important problems in biochemistry and enzymology. For example, we are investigating the source of the remarkable accuracy with which DNA polymerases copy our genetic information. The accuracy (fidelity) of DNA replication is an important issue in the development of cancer and hereditary diseases. The replication fidelity that is needed to maintain healthy populations can be best appreciated if one realizes that there are about one billion base pairs (letters of the genetic alphabet) in our genome. When a cell divides, all these base pairs must be copied without mistakes to constitute a genome of the new cell. Thus, the human DNA polymerases must make less than one mistake per one billion of copied bases. The energetics of the formation of the Watson-Crick hydrogen bonds between the complementary DNA bases in aqueous solution is not sufficient to explain such enormous fidelity. Our calculations search for the free energy sources of the DNA replication fidelity in binding of nucleotide triphosphate substrates (dNTPs) to DNA polymerases. In addition, we were able to simulate the actual chemical step-the formation of the phosphodiester bond in the active site of the enzyme. The analysis of the chemistry for the right and wrong nucleotides provides additional informations about the mechanisms and fidelity of DNA polymerases. Recently, a new class of DNA polymerases, the so called 'error-prone' polymerases, have been discovered both in bacterial and human cells. These new polymerases play an important role in the DNA repair, cancer, and they are also implicated in the differentiation of lymphocytes (hypermutation). Thus, the investigation of high-fidelity and error-prone DNA polymerases will remain the subject of our research also in future.
研究兴趣
论文共 123 篇作者统计合作学者相似作者
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Jazmin Calimano,Feifei Li,Jan Florián, Dalice M. Piñero-Cruz,Thomas R. Fielitz,Russell J. Holmes,Jacob W. Ciszek
The Cambridge Structural Database (2021)
Astronomy & astrophysics (2020): A41-A41
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作者统计
#Papers: 123
#Citation: 6830
H-Index: 44
G-Index: 81
Sociability: 5
Diversity: 0
Activity: 0
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