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The primary task of the nervous system is to process and store information, and we study how this is achieved at the level of RNA molecules. As an mRNA travels through the different cellular compartments, it passes through several regulatory stages. These stages are controlled by RNA-binding proteins (RBPs) and non-coding RNAs (ncRNAs), which assemble on the mRNA into a regulatory ribonucleoprotein complex (RNP). We developed iCLIP which revealed how the position of RBP-RNA interactions guides the RBP function. We characterized the function of several RBPs that are implicated in neurologic diseases, and revealed a mechanism that controls the emergence of new exons from transposable elements
Currently, we study the structure and function of regulatory RNPs in neurons and glia. Each RNP has a unique structure, which depends on the sequence-specific interactions between mRNA, RBPs and ncRNAs. To fully understand the dynamic structure of RNPs, we study them within intact cells. We integrate genomic, biochemical and computational techniques to study RNPs in brain tissue or in pluripotent stem cells that are differentiated into specific neuronal or glial cell types. Specifically, we aim to:
How do the RNA-RNA, protein-RNA and protein-protein interactions act together to define the assembly and function of regulatory RNPs?
How do RNPs guide the differentiation and functions of neurons or glial cells during brain development, aging or neurodegenerative diseases?
How do mutations cause disease by disrupting the function of RNPs or RNA regulatory elements, and what treatments could ameliorate this?
The primary task of the nervous system is to process and store information, and we study how this is achieved at the level of RNA molecules. As an mRNA travels through the different cellular compartments, it passes through several regulatory stages. These stages are controlled by RNA-binding proteins (RBPs) and non-coding RNAs (ncRNAs), which assemble on the mRNA into a regulatory ribonucleoprotein complex (RNP). We developed iCLIP which revealed how the position of RBP-RNA interactions guides the RBP function. We characterized the function of several RBPs that are implicated in neurologic diseases, and revealed a mechanism that controls the emergence of new exons from transposable elements
Currently, we study the structure and function of regulatory RNPs in neurons and glia. Each RNP has a unique structure, which depends on the sequence-specific interactions between mRNA, RBPs and ncRNAs. To fully understand the dynamic structure of RNPs, we study them within intact cells. We integrate genomic, biochemical and computational techniques to study RNPs in brain tissue or in pluripotent stem cells that are differentiated into specific neuronal or glial cell types. Specifically, we aim to:
How do the RNA-RNA, protein-RNA and protein-protein interactions act together to define the assembly and function of regulatory RNPs?
How do RNPs guide the differentiation and functions of neurons or glial cells during brain development, aging or neurodegenerative diseases?
How do mutations cause disease by disrupting the function of RNPs or RNA regulatory elements, and what treatments could ameliorate this?
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