基本信息
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职业迁徙
个人简介
My research program is divided into clinical investigation and basic research components. Clinical investigation approaches include studies aimed at identifying in vivo mechanisms underlying the pathogenesis of non-insulin dependent diabetes mellitus, obesity, and other disorders of insulin resistance. Studies are in progress to identify the relative role of each organ system (muscle, liver and fat) to the pathophysiology of NIDDM. In addition, a number of protocols are underway exploring new modes of therapy for established NIDDM as well as means of primary prevention for this disease. A major focus for the basic research program is to understand the molecular and cellular mechanisms of insulin and IGF-I action. An important emphasis is placed on understanding the structure/function relationship of the cognate receptors for these ligands. Approaches used include the use of site directed mutagenesis to modify the insulin and/or IGF-I receptor cDNAs followed by transfection of these modified cDNAs into host mammalian cells for biologic studies. Several functional domains of these receptor proteins have been identified which mediate the divergent and convergent signaling pathway of these two hormone receptor systems. For example, a domain of the insulin receptor has been identified which mediates the metabolic signaling properties of this receptor, whereas the other biologic effects of this receptor are intrinsic to other domains. The downstream signaling pathways of thee receptors are also under intensive investigation. These include studies of the mechanisms whereby insulin and IGF-I stimulate transcription of a series of early response genes and what are the signaling molecules which lie between the receptor and the DNA response elements which mediate these signaling pathways.
研究兴趣
论文共 775 篇作者统计合作学者相似作者
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bioRxiv the preprint server for biology (2024)
Roi Isaac,Gautam Bandyopadhyay,Theresa V. Rohm, Sion Kang, Jinyue Wang,Narayan Pokhrel,Sadatsugu Sakane,Rizaldy Zapata,Avraham M. Libster,Yaron Vinik, Asres Berhan,Tatiana Kisseleva, Zea Borok,Yehiel Zick,Francesca Telese,Nicholas J. G. Webster,Jerrold M. Olefsky
Annual review of physiology (2024): 225-253
Nature metabolismno. 8 (2024): 1646-1646
Souradipta Ganguly,Sara Brin Rosenthal, Kei Ishizuka,Ty D Troutman,Theresa V Rohm, Naser Khader, German Aleman-Muench, Yasuyo Sano, Sebastiano Archilei,Pejman Soroosh,Jerrold M Olefsky,Ariel E Feldstein,Tatiana Kisseleva,Rohit Loomba,Christopher K Glass,David A Brenner,Debanjan Dhar
Proceedings of the National Academy of Sciences of the United States of Americano. 35 (2024): e2405746121-e2405746121
Theresa V. Rohm, Felipe Castellani Gomes Dos Reis,Roi Isaac, Cairo Murphy,Karina Rocha,Gautam Bandyopadhyay,Hong Gao, Avraham M. Libster,Rizaldy C. Zapata,Yun Sok Lee,Wei Ying, Charlene Miciano, Allen Wang,Jerrold M. Olefsky
NATURE METABOLISM (2024)
Natalie DeForest,Babu Kavitha,Siqi Hu,Roi Isaac,Lynne Krohn,Minxian Wang,Xiaomi Du,Camila De Arruda Saldanha,Jenny Gylys, Edoardo Merli,Ruben Abagyan,Laeya Najmi,Viswanathan Mohan,Jason Flannick,Gina M. Petoso,Philip L. S. M. Gordts,Sven Heinz,Aimee M. Deaton,Amit V. Khera,Jerrold Olefsky,Venkatesan Radha,Amit R. Majithia
Cell genomicsno. 7 (2023): 100339-100339
Immunityno. 1 (2022): 31-55
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作者统计
#Papers: 773
#Citation: 100975
H-Index: 158
G-Index: 299
Sociability: 8
Diversity: 3
Activity: 156
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