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The election of Academicians of Academia Sinica recognizes outstanding scientists in three research divisions: Mathematics and Physical Sciences, Life Sciences, and Humanities and Social Sciences. Academicians of Academic Sinica are elected every two years at the Convocation of Academicians, and each division is permitted to elect no more than 10 Academicians at each Convocation.
Prof Wang’s main research interests are in cell signal transduction which is involved in essentially all biological processes from basic energy metabolism to highly elaborated processes such as cell growth and cell differentiation. By studying the operation of cell signaling, Prof Wang has made contributions to the discovery of a number of key proteins and their mechanisms. His research contributions include the purification of calmodulin and the demonstration of calcium ion dependence of calmodulin action, the discovery and purification of calcineurin as the major calmodulin binding protein in central nervous tissue, and the demonstration and purification of isoforms of calmodulin-dependent cyclic nucleotide phosphodiesteras. These discoveries established the pivotal role of calmodulin in Ca2+ signaling, laying foundations for the research of cell signal transduction and regulation.
Another groundbreaking work of Prof Wang is the discovery of the active Cdk5 (cyclin-dependent kinase 5) kinase complex as well as the identification of both Cdk5 activators. These findings has pointed to new research directions for nervous system development, brain function, and various neurological disorders, and has thus stimulated a wide interest in neuroscience. Moreover, his work has paved the way for the formation of a new area as Cdk5 in neuroscience. The research of Cdk5 in neurodegenerative diseases has also attracted extensive attention. Research work from Prof Wang’s group and other research groups has demonstrated that the deregulation of Cdk5 is a key step in the pathology of Alzheimer’s disease. His findings would have important implications to the identification of potential drugs for alleviating symptoms of Alzheimer’s disease.
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Afcs-nature Molecule Pages (2009)
Journal of Biological Chemistryno. 19 (1997): 12318-12327
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