基本信息
浏览量:111
职业迁徙
个人简介
For over two decades, my colleagues and I have used molecular genetics to clarify the molecular basis of cancer, focussing on the role of chromosome translocations in lymphoma development. We (and others) discovered that the hallmark translocation in Burkitt lymphoma activates the Myc proto-oncogene by coupling it to an immunoglobulin locus. To prove its etiological role, we showed that mice bearing a Myc transgene that mimics the chromosome junction are highly predisposed to lymphomagenesis. These transgenic mice and others we developed have proven very effective for dissecting tumorigenesis and, more recently, for studying new approaches to therapy. Our most influential discovery has been the critical role of impaired cell death in cancer development and resistance to therapy. Our laboratory revealed that the Bcl-2 gene, discovered by others via its translocation in follicular lymphoma, was oncogenic because it imposes cell survival. Bcl-2 has proven to be the prototype of a family of proteins whose interactions arbitrate the life and death of cells. We are now attempting to clarify how those interactions flip the cell death (apoptosis) switch, how the effectiveness of that switch is impaired in cancer cells and how it can be reactivated to improve cancer treatment.
研究兴趣
论文共 66 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
引用0浏览0引用
0
0
European Journal of Cancerno. SUPnan (2012): S11-S12
M F Van Delft,D P Smith,Mireille H Lahoud, D C Huang,Jerry M Adams,Jerry E Chipuk,Tudor Moldoveanu,Fabien Llambi,Melissa J Parsons,Ingo Ringshausen, A J Finch,Lamorna Brown Swigart
mag(2011)
引用74浏览0引用
74
0
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn