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Professor John Chiang’s lab purified and cloned the gene of cholesterol 7-hydroxylase (CYP7A1) in bile acid synthesis in hepatocytes. He studied the molecular mechanisms of bile acid feedback regulation of CYP7A1 transcription by nuclear receptors and transcription factors. His original research lead to the identification of bile acid-activated nuclear receptor FXR and the gut to liver axis in regulation of bile acid synthesis. His current research projects are focused on the role and mechanism of FXR and TGR5 signaling in regulation of bile acid, glucose, lipid and energy metabolism in non-alcoholic fatty liver disease, obesity and diabetes, and therapeutic treatments. His research projects have been funded continuously by NIH grants for over 33 years and received a MERIT award from NIDDK, NIH. He is an editor of Hepatology, Hepatology Communications and Gene Expression, and Executive Associate editor of Liver Research. He has published over 180 manuscripts and hold 8 US patents.
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论文共 244 篇作者统计合作学者相似作者
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Cellular and molecular gastroenterology and hepatology (2024)
Cellular and molecular gastroenterology and hepatologyno. 5 (2024): 719-735
Cellular and Molecular Gastroenterology and Hepatologyno. 5 (2024): 719-735
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Cardiology Plusno. 1 (2023): 46-52
Sabita Pokhrel,Matthew Dilts, Zachary Stahl,Shannon Boehme, Gabrielle Frame,John Y. L. Chiang,Jessica M. M. Ferrell
HEPATOLOGY COMMUNICATIONSno. 5 (2023)
The Journal of biological chemistryno. 5 (2023): 103070-104672
CURRENT OPINION IN GASTROENTEROLOGYno. 3 (2023): 249-255
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