基本信息
浏览量:7
职业迁徙
个人简介
Laboratory research since 1985 has focused on the nature and consequences of altered mucosal glycosylation in gastro-intestinal disease. Recently this has included study of (i) bacteria-diet-epithelial interactions in pathogenesis of inflammatory bowel diseases (Crohn's disease and ulcerative colitis) and colorectal cancer; (ii) the role of the human galactose-binding lectin, galectin-3, in cancer metastasis and its inhibition by modified heparins.
The altered mucosal glycosylation we found in inflammatory bowel disease and colon cancer led to studies co-led by Prof Barry Campbell (qv) investigating the mucosa-associated microbiota. Working with the late Prof Tony Hart (Med Microbiol) we found increased mucosa-associated E. coli in Crohn’s disease and colon cancer (Martin H et al Gastroenterology 2004;127:80-93). This complimented studies by Swidsinski et al and Darfeuille-Michaud et al , and since confirmed by many others. Collaboration with Christian Jobin showed that mucosal E. coli expressing the polyketide gene complex (pks) that leads to production of the genotoxin colibactin is associated with human sporadic colon cancer and also induces experimental inflammation-related colon cancer (Arthur JC et al Science 2012;338:120-3; Prorok-Hamon M et al Gut 2014;63:761-70). Further studies investigated interactions between mucosal E. coli and macrophages in Crohn’s disease (Mpofu et al, Gastroenterology 2007;133:1487-98; Subramanian S et al Antimicrob Agents Chemother 2008;52:427-34; Flanagan P et al IBDJ Dis 2015;21:1499-510).
研究兴趣
论文共 495 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
openalex(2023)
Sreedhar Subramanian,Jonathan M. Rhodes,Joseph M. Taylor,Anna M. Milan,Steven Lane,Martin Hewison,Rene F. Chun,Andrea Jorgensen,Paul Richardson, Darshan Nitchingham,Joseph Aslan, Maya Shah, Coonoor R. Chandrasekar,Amanda Wood,Mike Beadsworth,Munir Pirmohamed
Hannah L. Simpson,Carol L. Roberts,Louise M. Thompson, Cameron R. Leiper, Nehana Gittens, Ellie Trotter,Carrie A. Duckworth,Stamatia Papoutsopoulou,Fabio Miyajima,Paul Roberts,Niamh O'Kennedy,Jonathan M. Rhodes,Barry J. Campbell
ALIMENTARY PHARMACOLOGY & THERAPEUTICSno. 1 (2021): 4-5
加载更多
作者统计
#Papers: 494
#Citation: 17193
H-Index: 68
G-Index: 123
Sociability: 7
Diversity: 0
Activity: 1
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn