基本信息
浏览量:2
职业迁徙
个人简介
Research Description:
Building a functioning brain requires the establishment of an elaborate network of interactions between neurons and non-neuronal glial cells. Defects in neuron-glia interactions are implicated in many neurological disorders, including autism, schizophrenia, Alzheimer’s Disease, neurodegeneration, neuropathic pain, and neuroimmune disorders. Astrocytes, a major glial cell type in the brain, are morphologically complex cells that extensively infiltrate the neuropil to directly interact with neurons and all other brain cell types. Through this extensive network of interactions, astrocytes control a wide variety of processes that are fundamentally important for proper brain development and function, including synapse formation, regulation of neurotransmission, and establishment of the blood-brain barrier. Despite the many important roles of astrocytes in the brain, we still have a limited understanding of the mechanisms that regulate the development of astrocytes and their interactions with other cells. Moreover, we do not know how defects in these processes drive neurological dysfunction. To address these important knowledge gaps, my laboratory is investigating fundamental aspects of astrocyte cell biology to understand how astrocytes, through their interactions with other brain cell types, regulate brain development and function. Furthermore, we study how astrocyte dysfunction drives the pathogenesis of neurological disorders such as autism, schizophrenia, and leukodystrophy. We use a variety techniques, including mouse genetics, primary cell culture, quantitative proteomics, molecular biology, and super resolution microscopy to probe the function of astrocytes during brain development and disease.
研究兴趣
论文共 15 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Trends in Cell Biology (2023)
Current opinion in neurobiology (2023): 102704-102704
Alex R Eaker,Katherine T Baldwin
Journal of visualized experiments : JoVE (2022)
Rafi Kohen,Katherine T. Baldwin,Patricia M. Garay, Takao Tsukahara, Alex Chen,Corey G. Flynn,Craig Johnson,Xiao-Feng Zhao,Michael A. Sutton,Shigeki Iwase,Roman J. Giger
biorxiv(2020)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn