Konstanze Hurth - Novartis Institutes for BioMedical Research, Neuroscience Research, CH-4002 Basel, Switzerland

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Ligandability Assessment of IL-1β by Integrated Hit Identification Approaches

Anna Vulpetti,Jean-Michel Rondeau, Marie-Hélène Bellance,Jutta Blank, Ralf Boesch,Andreas Boettcher,Frédéric Bornancin, Sylvia Buhr, Lauren E Connor, Christoph E Dumelin, Oliver Esser, Michael Hediger,

Journal of medicinal chemistry (2024)

引用0浏览0WOS引用

Discovery of a selective and biologically active low-molecular weight antagonist of human interleukin-1β

Ulrich Hommel,Konstanze Hurth,Jean-Michel Rondeau,Anna Vulpetti, Daniela Ostermeier,Andreas Boettcher, Jacob Peter Brady, Michael Hediger,Sylvie Lehmann, Elke Koch,Anke Blechschmidt, Rina Yamamoto,

Nature Communications（2023）

引用1浏览0WOSNATURE引用

Synthesis Of The Potent, Selective, And Efficacious Beta-Secretase (Bace1) Inhibitor Nb-360

Heinrich Rueeger,Rainer Lueoend,Rainer Machauer,Siem J Veenstra,Philipp Holzer,Konstanze Hurth,Markus Voegtle,Mathias Frederiksen,Jean-Michel Rondeau,Marina Tintelnot-Blomley,Laura H Jacobson,Matthias Staufenbiel,

JOURNAL OF MEDICINAL CHEMISTRY（2021）

引用6浏览0WOS引用

Discovery of Umibecestat (CNP520): A Potent, Selective, and Efficacious beta-Secretase (BACE1) Inhibitor for the Prevention of Alzheimer's Disease

Rainer Machauer,Rainer Lueoend,Konstanze Hurth,Siem J Veenstra,Heinrich Rueeger,Markus Voegtle,Marina Tintelnot-Blomley,Jean-Michel Rondeau,Laura H Jacobson,Grit Laue,Karen Beltz,Ulf Neumann

JOURNAL OF MEDICINAL CHEMISTRY（2021）

引用6浏览0WOS引用

The BACE ‐1 inhibitor CNP 520 for prevention trials in Alzheimer's disease

Ulf Neumann,Mike Ufer,Laura H Jacobson,Marie‐Laure Rouzade‐Dominguez,Gunilla Huledal,Carine Kolly,Rainer M Lüönd,Rainer Machauer,Siem J Veenstra,Konstanze Hurth,Heinrich Rueeger,Marina Tintelnot‐Blomley,

EMBO Molecular Medicineno. 11 (2018)

引用94浏览0引用

The BACE-1 inhibitor CNP520 for prevention trials in Alzheimer's disease

Ulf Neumann,Mike Ufer,Laura H Jacobson,Marie-Laure Rouzade-Dominguez,Gunilla Huledal,Carine Kolly,Rainer M Lüönd,Rainer Machauer,Siem J Veenstra,Konstanze Hurth,Heinrich Rueeger,Marina Tintelnot-Blomley,

EMBO MOLECULAR MEDICINE（2018）

引用117浏览0WOS引用

117

Discovery of amino-1,4-oxazines as potent BACE-1 inhibitors

Siem Jakob Veenstra,Heinrich Rueeger,Markus Voegtle,Rainer Lueoend,Philipp Holzer,Konstanze Hurth,Marina Tintelnot-Blomley,Mathias Frederiksen,Jean-Michel Rondeau,Laura Jacobson,Matthias Staufenbiel,Ulf Neumann,

Bioorganic & Medicinal Chemistry Letters（2018）

引用8浏览0WOS引用

ChemInform Abstract: Regioselective Nitration of 3‐Fluoro‐2‐Substituted Benzoic Acids

Konstanze Hurth,Sebastien Jacquier, Hansjoerg Lehmann,Rainer Wilcken

Cheminform（2015）

引用1浏览0引用

SUBSTITUTED QUINAZOLIN-4-ONE DERIVATIVES

D U Zhenxing,Samuel Hintermann,Konstanze Hurth, Sebastien Jacquier, Hansjoerg Lehmann,Henrik Moebitz, Nicolas Soldermann,Aleksandar Stojanovic

mag（2015）

引用23浏览0引用

Regioselective nitration of 3-fluoro-2-substituted benzoic acids

Konstanze Hurth,Sebastien Jacquier, Hansjorg Lehmann,Rainer Wilcken

Tetrahedron Letters（2015）

引用6浏览0引用

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