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Lee Rubin investigates the key molecular mediators of different neurodegenerative diseases, with the ultimate goal of finding effective preclinical therapeutic candidates. His research group discovered that a circulating protein, GDF11, has the ability to reverse some of the changes in the CNS associated with aging. They are actively exploring the therapeutic implications of these observations.
The Rubin group takes advantage of their ability to produce large numbers of patient-derived induced pluripotent stem (iPS) cell lines and of effective means of deriving large numbers of differentiated neurons from them. They have set up an array of techniques that allow them to identify early cellular and physiological changes in neurons as they become diseased. For example, they have identified new targets for the treatment of the motor neuron disorders Spinal Muscular Atrophy (SMA) and Amyotrophic Lateral Sclerosis (ALS). They are also studying Autism Spectrum Disorders, Parkinson’s disease and Alzheimer’s disease.
The Rubin group takes advantage of their ability to produce large numbers of patient-derived induced pluripotent stem (iPS) cell lines and of effective means of deriving large numbers of differentiated neurons from them. They have set up an array of techniques that allow them to identify early cellular and physiological changes in neurons as they become diseased. For example, they have identified new targets for the treatment of the motor neuron disorders Spinal Muscular Atrophy (SMA) and Amyotrophic Lateral Sclerosis (ALS). They are also studying Autism Spectrum Disorders, Parkinson’s disease and Alzheimer’s disease.
研究兴趣
论文共 273 篇作者统计合作学者相似作者
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bioRxiv (Cold Spring Harbor Laboratory) (2024): 1327361-1327361
Martin H. Berryer, Gizem Rizki, Anna Nathanson,Jenny A. Klein,Darina Trendafilova,Sara G. Susco,Daisy Lam,Angelica Messana,Kristina M. Holton,Kyle W. Karhohs,Beth A. Cimini,Kathleen Pfaff,
biorxiv(2023)
Dylan V Neel,Himanish Basu,Georgia Gunner, Matthew D Bergstresser,Richard M Giadone,Haeji Chung,Rui Miao,Vicky Chou, Eliza Brody,Xin Jiang,Edward Lee,Michelle E Watts,
Laura Ben Driss, John Lian,Ryan G Walker, James A Howard,Thomas B Thompson,Lee L Rubin,Amy J Wagers,Richard T Lee
The journal of cardiovascular agingno. 4 (2023)
Francesca Rapino,Ted Natoli,Francesco Limone, Erin O'Connor,Jack Blank,Matthew Tegtmeyer,William Chen, Erika Norabuena, Juhi Narula,Dane Hazelbaker,Gabriella Angelini,Lindy Barrett,
NATURE COMMUNICATIONSno. 1 (2023)
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Nature Communicationsno. 1 (2023): 1-18
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