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The overall focus of our research is on characterizing the mechanism of activation, deactivation and desensitization of glutamate receptor-channel proteins that are heterologously expressed in mammalian cells and in native neurons in primary culture. The biological impetus for our research is to understand how the diverse functions of the three subfamilies of glutamate receptors (AMPA, kainate and NMDA), which have pre-post- and extrasynaptic roles in the brain, are related to their intrinsic biophysical properties. In the last five years we have collaborated with Dr. Gabriela Popescu at the University of Buffalo and Dr. Robert Oswald in our department, performing detailed kinetic analysis of wild type NMDA (neuronal) and AMPA receptor-channels expressed in human embryonic kidney cells. Our new work is focused on making point mutations in a part of a model AMPA receptor hypothesized to be involved in the transfer of energy from agonist binding to the opening the channel pore. A second project involves studying the influence of cytoplasmic factors on the function of single AMPA receptor-channels in cell-attached and excised inside-out membrane patches.
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IONOTROPIC GLUTAMATE RECEPTOR TECHNOLOGIES (2016)
Journal of physiologyno. 19 (2009): 4563-4564
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#Papers: 41
#Citation: 7863
H-Index: 21
G-Index: 33
Sociability: 4
Diversity: 3
Activity: 0
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