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Our research program is devoted to applying physical and synthetic chemical methods to solving problems of biological and medical relevance. We explore the fundamental chemistry of simpler compounds as well as large biomolecules with the goal of understanding how metal species function in complex living systems. Toward this end, we rely heavily on both synthetic chemistry and on physical techniques including 2D and dynamic NMR and X-ray crystallography. We often undertake rate studies to determine the relationship between structure and reactivity. Members of my group have diverse research opportunities ranging from the exclusively synthetic to the exclusively quantitative. Transition metal species are found in compounds essential for life-Co in vitamin B-12, Fe in hemoglobin, and Zn, Cu, Mo, etc., in metalloenzymes. Metals have been incorporated into drugs (Pt in anticancer agents, Au in antiarthritic agents) and in diagnostic
contrast agents (Tc, Gd) and also may function as pollutants (Cd, Hg, Pb and others).
contrast agents (Tc, Gd) and also may function as pollutants (Cd, Hg, Pb and others).
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Inorganic Chemistryno. 16 (2017): 9781-9793
semanticscholar(2015)
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