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个人简介
My research is primarily focused on molecular mechanisms underlying the pathogenesis of Alzheimer’s disease (AD). My graduate work in the laboratory of Dr. M. Victoria Clos in the Department of Pharmacology at the Autonomous University of Barcelona was focused on studying the relationship between prion proteins (PrP) and acetylcholinesterase (AChE), both of which are present in the senile plaques found in Alzheimer disease (AD) brain, and whether AChE could stimulate PrP aggregation in the context of AD. I found that this was indeed the case, and that inhibitors of AChE could inhibit PrP aggregation. This work highlighted the role of AChE in triggering amyloidogenesis, and pointed towards ways of inhibiting this process.
My work in the laboratory of Dr. Alberto Lleó in the Department of Neurology in the Hospital de la Santa Creu i Sant Pau, also in Barcelona, continued my interest in neurodegeneration, focusing on the cell biology of Alzheimer disease. I found that cholesterol, which has been implicated in AD pathogenesis, is involved in the regulation of the subcellular trafficking of the amyloid precursor protein (APP), and that there were distinct patterns in the processing of APP by both β-secretase (BACE1) and γ-secretase in patients with familial and sporadic AD.
As a Postdoctoral Fellow at Columbia University (New York, USA) under the supervision of Dr. Eric Schon and Dr. Estela Area-Gomez, I became proficient in methods used to measure mitochondria-associated ER membranes (MAM) functionality and mitochondrial function and dynamics. Dr. Schon’s laboratory has had a long-standing interest in human mitochondrial genetics and disease, and much of their efforts over the past 30 years have focused on understanding the pathogenesis and treatment of these fatal disorders. Dr. Area-Gomez is a world expert in MAM and lipid homeostasis. During my postdoctoral training at Columbia University, I made an unexpected finding that aberrant processing of APP has a profound effect on mitochondrial bioenergetics due to the detrimental effect of APP cleavage product, C99, on MAM and lipid homeostasis. This result suggests that the mitochondrial disturbances seen in AD patients are almost certainly not downstream ‘secondary’ features, but rather are a primary event in Alzheimer Disease pathogenesis.
At the end of 2019 I have joined Dr. Núria Casal’s group (International University of Catalunya, Barcelona, Spain) that has a broad expertise in metabolism, fulfilling the requirements I need to develop my actual research project. I now plan to follow up on the exciting finding I made at Columbia, focusing on trying to determine the mechanistic connection between APP processing, lipid dyshomeostasis, and mitochondrial bioenergetics. This acquired insight will open the door for the discovery of novel therapeutic targets that have been poorly explored and move from lipids to the modulation of the ER-mitochondrial communication.
研究兴趣
论文共 35 篇作者统计合作学者相似作者
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Research Square (Research Square) (2022)
biorxiv(2022)
NEUROBIOLOGY OF DISEASE (2020): 105062-105062
Neurobiology of disease (2020): 105062-105062
M. Pera,D. Larrea,J. Montesinos,C. Guardia-Laguarta, R.R. Agrawal, K.R. Velasco,Y. Xu,SY Koo,A Snead, A. Sproul,E. Area-Gomez
bioRxiv (2019)
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作者统计
#Papers: 35
#Citation: 1139
H-Index: 16
G-Index: 22
Sociability: 5
Diversity: 2
Activity: 5
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