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职业迁徙
个人简介
Degree in Pharmaceutical Sciences (FFUP, 1992-1998); PhD in Biochemistry (FFUP, 1999-2003); Postdoctoral scholar in Health Sciences (IBMC/UP, 2004-2010). Assistant Professor at the Faculty of Pharmacy University of Porto (2010-present).
The main goal of my research work has been the study of mediators’ determinant in immunopathology associated with infection, using the mice model to intervene and avoid pathology. The determination of the functional properties of a Trypanosoma cruzi-released protein (Tc52) and its influence on the phenotype evolution of experimental T. cruzi infection was done. The study and identification of important host factors and pathways in the immunopathology associated with Mycobacterium avium infection were also explored and identified. Nanoparticles containing anti-tuberculosis drugs are being tested using an M. avium infection in vitro experimental models. Research in the field of experimental toxoplasmosis is being performed, namely the manufacture of a nano vaccine containing selected parasite immunogens able to induce protection against Toxoplasma gondii. This study will allow us to survey immune responses and putative protection against infection induced by the nano vaccine using an established murine in vivo model of congenital toxoplasmosis. The screening of anti-parasitic molecules using an T. gondii infection in vitro model is also an important aspect in the search for new agents effective against acute and chronic infection.
研究兴趣
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Vaccinesno. 4 (2023): 733-733
Toxicology (2022): 153282-153282
Frontiers in Immunology (2021)
bioRxiv (Cold Spring Harbor Laboratory) (2021)
Mariana Barros, Daniela Teixeira,Manuel Vilanova,Alexandra Correia,Natercia Teixeira,Margarida Borges
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