基本信息
浏览量:4
职业迁徙
个人简介
Dr. Telen is recognized as an expert in the biochemistry and molecular genetics of blood group antigens and the pathophysiological mechanisms of vaso-occlusion in sickle cell disease. She is the Director of the Duke Comprehensive Sickle Cell Center.
Dr. Telen's laboratory focuses on structure/function analysis of membrane proteins expressed by erythroid cells, as well as the role of these proteins in non-erythroid cells. Proteins are also studied in transfectant systems, and research focuses especially on adhesion receptors. The goals of this work are (1) to understand the mechanism and role of red cell adhesion to leukocytes and endothelium in sickle cell disease; (2) to understand the signaling mechanisms leading to activation (and inactivation) of red cell adhesion molecules; (3) to understand the molecular basis of blood group antigen expression, and (4) to understand the interactions of erythroid membrane proteins with other cells and with extracellular matrix..
Recent investigations have focused on the role of signaling pathways in the upregulation of sickle red cell adhesion. Present studies include (1) investigation of beta-adrenergic signaling pathway responsible for activation of B-CAM/LU and LW adhesion receptors; (2) understanding how nitric oxide and ATP downregulate sickle red cell adhesion; (3) studying the effect of these processes in animal models.
Dr. Telen is also involved in a large multicenter study looking for genetic polymorphisms that affect clinical outcomes in sickle cell disease, as well as a multi-center study investigating the mechanisms and treatment of pulmonary hypertension in sickle cell disease.
Key Words:
Adhesion molecules
Erythrocyte membrane
Sickle cell disease
Transfusion medicine
Immunohematology
CD44
B-CAM/LU
Genetic polymorphisms
Dr. Telen's laboratory focuses on structure/function analysis of membrane proteins expressed by erythroid cells, as well as the role of these proteins in non-erythroid cells. Proteins are also studied in transfectant systems, and research focuses especially on adhesion receptors. The goals of this work are (1) to understand the mechanism and role of red cell adhesion to leukocytes and endothelium in sickle cell disease; (2) to understand the signaling mechanisms leading to activation (and inactivation) of red cell adhesion molecules; (3) to understand the molecular basis of blood group antigen expression, and (4) to understand the interactions of erythroid membrane proteins with other cells and with extracellular matrix..
Recent investigations have focused on the role of signaling pathways in the upregulation of sickle red cell adhesion. Present studies include (1) investigation of beta-adrenergic signaling pathway responsible for activation of B-CAM/LU and LW adhesion receptors; (2) understanding how nitric oxide and ATP downregulate sickle red cell adhesion; (3) studying the effect of these processes in animal models.
Dr. Telen is also involved in a large multicenter study looking for genetic polymorphisms that affect clinical outcomes in sickle cell disease, as well as a multi-center study investigating the mechanisms and treatment of pulmonary hypertension in sickle cell disease.
Key Words:
Adhesion molecules
Erythrocyte membrane
Sickle cell disease
Transfusion medicine
Immunohematology
CD44
B-CAM/LU
Genetic polymorphisms
研究兴趣
论文共 391 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Grace M. Lee,Milena Batchvarova,Martha Delahunty, Lydia Boateng,Kimberly Boyle, Mark A. Suggs,Marilyn J. Telen
Ronan P. Sugrue, Marie Elise Abi Antoun, Jaxon Olsen, Alexandra Stonehill,Jennifer J. Cate,Virginia Y. Watkins, Lesley Skalla,Marilyn Telen, Andra H. James,Jerome J. Federspiel
American Journal of Obstetrics and Gynecologyno. 1 (2024): S41
Rebecca Keener,Surya B Chhetri,Carla J Connelly,Margaret A Taub,Matthew P Conomos,Joshua Weinstock,Bohan Ni,Benjamin Strober,Stella Aslibekyan,Paul L Auer,Lucas Barwick,Lewis C Becker,John Blangero,Eugene R Bleecker,Jennifer A Brody,Brian E Cade,Juan C Celedon,Yi-Cheng Chang,L Adrienne Cupples,Brian Custer,Barry I Freedman,Mark T Gladwin,Susan R Heckbert,Lifang Hou,Marguerite R Irvin,Carmen R Isasi,Jill M Johnsen,Eimear E Kenny,Charles Kooperberg,Ryan L Minster,Take Naseri,Satupa'itea Viali,Sergei Nekhai,Nathan Pankratz,Patricia A Peyser,Kent D Taylor,Marilyn J Telen,Baojun Wu,Lisa R Yanek,Ivana V Yang,Christine Albert,Donna K Arnett,Allison E Ashley-Koch,Kathleen C Barnes,Joshua C Bis,Thomas W Blackwell,Eric Boerwinkle,Esteban G Burchard,April P Carson,Zhanghua Chen,Yii-Der Ida Chen,Dawood Darbar,Mariza de Andrade,Patrick T Ellinor,Myriam Fornage,Bruce D Gelb,Frank D Gilliland,Jiang He,Talat Islam,Stefan Kaab,Sharon L R Kardia,Shannon Kelly,Barbara A Konkle,Rajesh Kumar,Ruth J F Loos,Fernando D Martinez,Stephen T McGarvey,Deborah A Meyers,Braxton D Mitchell,Courtney G Montgomery,Kari E North,Nicholette D Palmer,Juan M Peralta,Benjamin A Raby,Susan Redline,Stephen S Rich,Dan Roden,Jerome I Rotter,Ingo Ruczinski,David Schwartz,Frank Sciurba,M Benjamin Shoemaker,Edwin K Silverman,Moritz F Sinner,Nicholas L Smith,Albert V Smith,Hemant K Tiwari,Ramachandran S Vasan,Scott T Weiss,L Keoki Williams,Yingze Zhang,Elad Ziv,Laura M Raffield,Alexander P Reiner, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium,TOPMed Hematology and Hemostasis Working Group,TOPMed Structural Variation Working Group,Marios Arvanitis,Carol W Greider,Rasika A Mathias,Alexis Battle
Nature communicationsno. 1 (2024)
Xinruo Zhang,Jennifer A Brody,Mariaelisa Graff,Heather M Highland,Nathalie Chami,Hanfei Xu,Zhe Wang,Kendra Ferrier,Geetha Chittoor,Navya S Josyula,Xihao Li,Zilin Li,Matthew A Allison,Diane M Becker,Lawrence F Bielak,Joshua C Bis,Meher Preethi Boorgula,Donald W Bowden,Jai G Broome,Erin J Buth,Christopher S Carlson,Kyong-Mi Chang,Sameer Chavan,Yen-Feng Chiu,Lee-Ming Chuang,Matthew P Conomos,Dawn L DeMeo,Margaret Du,Ravindranath Duggirala,Celeste Eng,Alison E Fohner,Barry I Freedman,Melanie E Garrett,Xiuqing Guo,Chris Haiman,Benjamin D Heavner,Bertha Hidalgo,James E Hixson,Yuk-Lam Ho,Brian D Hobbs,Donglei Hu,Qin Hui,Chii-Min Hwu,Rebecca D Jackson,Deepti Jain,Rita R Kalyani,Sharon L R Kardia,Tanika N Kelly,Ethan M Lange,Michael LeNoir,Changwei Li,Loic Le Marchand,Merry-Lynn N McDonald,Caitlin P McHugh,Alanna C Morrison,Take Naseri,Jeffrey O'Connell,Christopher J O'Donnell,Nicholette D Palmer,James S Pankow,James A Perry,Ulrike Peters,Michael H Preuss,D C Rao,Elizabeth A Regan,Sefuiva M Reupena,Dan M Roden,Jose Rodriguez-Santana,Colleen M Sitlani,Jennifer A Smith,Hemant K Tiwari,Ramachandran S Vasan,Zeyuan Wang,Daniel E Weeks,Jennifer Wessel,Kerri L Wiggins,Lynne R Wilkens,Peter W F Wilson,Lisa R Yanek,Zachary T Yoneda,Wei Zhao,Sebastian Zöllner,Donna K Arnett,Allison E Ashley-Koch,Kathleen C Barnes,John Blangero,Eric Boerwinkle,Esteban G Burchard,April P Carson,Daniel I Chasman,Yii-Der Ida Chen,Joanne E Curran,Myriam Fornage,Victor R Gordeuk,Jiang He,Susan R Heckbert,Lifang Hou,Marguerite R Irvin,Charles Kooperberg,Ryan L Minster,Braxton D Mitchell,Mehdi Nouraie,Bruce M Psaty,Laura M Raffield,Alexander P Reiner,Stephen S Rich,Jerome I Rotter,M Benjamin Shoemaker,Nicholas L Smith,Kent D Taylor,Marilyn J Telen,Scott T Weiss,Yingze Zhang, Nancy Heard- Costa,Yan V Sun,Xihong Lin,L Adrienne Cupples,Leslie A Lange,Ching-Ti Liu,Ruth J F Loos,Kari E North,Anne E Justice
medRxiv : the preprint server for health sciences (2023)
Liam D Cato,Rick Li,Henry Y Lu,Fulong Yu,Mariel Wissman,Baraka S Mkumbe,Supachai Ekwattanakit,Patrick Deelen,Liberata Mwita,Raphael Sangeda,Thidarat Suksangpleng,Suchada Riolueang,Paola G Bronson,Dirk S Paul,Emily Kawabata,William J Astle,Francois Aguet,Kristin Ardlie,Aitzkoa Lopez de Lapuente Portilla,Guolian Kang,Yingze Zhang,Seyed Mehdi Nouraie,Victor R Gordeuk,Mark T Gladwin,Melanie E Garrett,Allison Ashley-Koch,Marilyn J Telen,Brian Custer,Shannon Kelly,Carla Luana Dinardo,Ester C Sabino,Paula Loureiro,Anna Bárbara Carneiro-Proietti,Cláudia Maximo, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, BIOS Consortium,Adriana Méndez,Angelika Hammerer-Lercher,Vivien A Sheehan,Mitchell J Weiss,Lude Franke,Björn Nilsson,Adam S Butterworth,Vip Viprakasit,Siana Nkya,Vijay G Sankaran
medRxiv the preprint server for health sciences (2023)
Gareth Hawkes,Robin N Beaumont,Zilin Li,Ravi Mandla,Xihao Li,Christine M. Albert,Donna K. Arnett,Allison E. Ashley-Koch, Aneel A. Ashrani,Kathleen C. Barnes,Eric Boerwinkle,Jennifer A. Brody,April P. Carson,Nathalie Chami,Yii-Der Ida Chen,Mina K. Chung,Joanne E. Curran,Dawood Darbar,Patrick T. Ellinor, Myrian Fornage,Victor R. Gordeuk,Xiuqing Guo,Jiang He,Chii-Min Hwu,Rita R. Kalyani,Robert Kaplan,Sharon L.R. Kardia,Charles Kooperberg,Ruth J.F. Loos,Steven A. Lubitz,Ryan L. Minster,Braxton D. Mitchell,Joanne M. Murabito,Nicholette D. Palmer,Bruce M. Psaty,Susan Redline,M. Benjamin Shoemaker,Edwin K. Silverman,Marilyn J. Telen,Scott T. Weiss,Lisa R. Yanek,Hufeng Zhou, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium,Ching-Ti Liu,Kari E. North,Anne E. Justice, Jon Locke,Nick Owens,Anna Murray,Kashyap Patel,Timothy M. Frayling,Caroline F. Wright,Andrew R. Wood,Xihong Lin,Alisa Manning,Michael N. Weedon
biorxiv(2023)
Goo Jun,Adam C English,Ginger A Metcalf,Jianzhi Yang,Mark Jp Chaisson,Nathan Pankratz,Vipin K Menon,William J Salerno,Olga Krasheninina,Albert V Smith,John A Lane,Tom Blackwell,Hyun Min Kang,Sejal Salvi,Qingchang Meng,Hua Shen,Divya Pasham,Sravya Bhamidipati,Kavya Kottapalli,Donna K Arnett,Allison Ashley-Koch,Paul L Auer,Kathleen M Beutel,Joshua C Bis,John Blangero,Donald W Bowden,Jennifer A Brody,Brian E Cade,Yii-Der Ida Chen,Michael H Cho,Joanne E Curran,Myriam Fornage,Barry I Freedman,Tasha Fingerlin,Bruce D Gelb,Lifang Hou,Yi-Jen Hung,John P Kane,Robert Kaplan,Wonji Kim,Ruth J F Loos,Gregory M Marcus,Rasika A Mathias,Stephen T McGarvey,Courtney Montgomery,Take Naseri,S Mehdi Nouraie,Michael H Preuss,Nicholette D Palmer,Patricia A Peyser,Laura M Raffield,Aakrosh Ratan,Susan Redline,Sefuiva Reupena,Jerome I Rotter,Stephen S Rich,Michiel Rienstra,Ingo Ruczinski,Vijay G Sankaran,David A Schwartz,Christine E Seidman,Jonathan G Seidman,Edwin K Silverman,Jennifer A Smith,Adrienne Stilp,Kent D Taylor,Marilyn J Telen,Scott T Weiss,L Keoki Williams,Baojun Wu,Lisa R Yanek,Yingze Zhang,Jessica Lasky-Su,Marie Claude Gingras,Susan K Dutcher,Evan E Eichler,Stacey Gabriel,Soren Germer,Ryan Kim,Karine A Viaud-Martinez,Deborah A Nickerson, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium,James Luo,Alex Reiner,Richard A Gibbs,Eric Boerwinkle,Goncalo Abecasis,Fritz J Sedlazeck
Research square (2023)
Drugs & agingno. 4 (2023): 317-334
加载更多
作者统计
#Papers: 391
#Citation: 11785
H-Index: 59
G-Index: 102
Sociability: 7
Diversity: 3
Activity: 72
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn