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个人简介
Dr. Scott’s laboratory is primarily focused on three primary areas of research: 1) investigation of the potential therapeutic use of “immunocamouflaged” cells/tissues in transfusion and transplantation medicine; 2) prevention of viral invasion via viral inactivation and target cell modification via immunocamouflage; and 3) examining whether the intraerythrocytic chelation and redox-inactivation of the hemoglobin-derived heme and iron present in the sickle and thalassemic RBC can slow/prevent premature red cell destruction.
Immunocamouflage of foreign cells and tissues is accomplished via the covalent modification of the cell membrane with nonimmunogenic materials such as methoxypoly(ethylene glycol). This nonimmunogenic barrier prevents the recognition of antigenic sites on the cell membrane by preexisting antibodies –hence preventing immunological rejection – and significantly diminishes the immunogenicity of the foreign cellular epitopes. Ongoing projects within the laboratory include the modification of red blood cells to prevent alloimmunization in the chronically transfused (e.g., sickle cell, thalassemic, autoimmune hemolytic anemia) patient; the prevention of graft versus host disease via lymphocyte modification; and the modification of pancreatic islets for tissue transplantation in diabetes.
Immunocamouflage of foreign cells and tissues is accomplished via the covalent modification of the cell membrane with nonimmunogenic materials such as methoxypoly(ethylene glycol). This nonimmunogenic barrier prevents the recognition of antigenic sites on the cell membrane by preexisting antibodies –hence preventing immunological rejection – and significantly diminishes the immunogenicity of the foreign cellular epitopes. Ongoing projects within the laboratory include the modification of red blood cells to prevent alloimmunization in the chronically transfused (e.g., sickle cell, thalassemic, autoimmune hemolytic anemia) patient; the prevention of graft versus host disease via lymphocyte modification; and the modification of pancreatic islets for tissue transplantation in diabetes.
研究兴趣
论文共 150 篇作者统计合作学者相似作者
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Transfusionno. 2 (2021): 448-456
EJHaemno. 1 (2021): 63-71
Beta Thalassemia (2020)
Immunosuppression (2020)
Cryopreservation - Current Advances and Evaluations (2020)
Current and Future Aspects of Nanomedicine (2020)
Anna-Barbara Moscicki,Tzy-Jyun Yao,Jonathan S. Russell,Sepideh Farhat,Mark Scott,Larry Magpantay,Gordana Halec,Caroline H. Shiboski,Mark Ryder, Ester Yang, William Shearer, Mary Paul, Norma Cooper, Lynette Harris, Karen Kemp-Posterman, Selene Wun, Murli Purswani, Mahboobullah Baig, Anna Cintron, Jennifer Zeni, Ana Puga, Sandra Navarro, Doyle Patton, Deyana Leon, Man Wai Ng, Sandra Burchett, Nancy Karthas, Betsy Kammerer, Ray Jurado, Johnny Kuttab, Ashlee Vorachek, Ram Yogev, Margaret Ann Sanders, Kathleen Malee, Scott Hunter, Victor Badner, Ronald Garreett, Andrew Wiznia, Marlene Burey, Molly Nozyce, Susan Chialastri, Janet Chen, Latreca Ivey, Maria Garcia Bulkley, Mitzie Grant, Ramon Gonzalez, Midnela Acevedo-Flores, Heida Rios, Vivian Olivera, Janice Townsend, Margarita Silio, Medea Jones, Patricia Sirois, Roopa Gandhi, Elizabeth McFarland, Emily Barr, Robin McEvoy, Kenneth Markowitz, Arry Dieudonne, Linda Bettica, Susan Adubato
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作者统计
#Papers: 149
#Citation: 4920
H-Index: 41
G-Index: 65
Sociability: 5
Diversity: 3
Activity: 1
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