基本信息
浏览量:17
职业迁徙
个人简介
Our goal is to understand the relationship between the molecular mechanisms that shape phenotypes within individuals and the evolutionary mechanisms that generate and maintain phenotypic variation within populations. This project requires that we identify the functional allelic variants that segregate in nature, understand their molecular mechanisms, characterize their population genetic dynamics, and build models that explain these dynamics in terms of molecular biology and ecology.
We use molecular and quantitative genetics to discover the alleles that underlie phenotypic variation. Our primary model system is C. elegans, a bacteria-eating nematode widely distributed across the globe. Natural isolates of this species harbor variation for development, morphology, behavior, and physiology (indeed, for almost any trait we can measure). A particular focus of our research is the genetic basis of gene expression variation; insofar as spatial and temporal regulation of gene activity underlies development, genetic analysis of gene expression variation provides a unique window into the substrate of developmental evolution. Moreover, by measuring thousands of gene expression traits simultaneously, we can leverage their correlation structure to infer the causal networks that constitute the genotype-phenotype map, potentially a major shaper of phenotypic divergence.
Our genome-scale analyses form the basis for our studies of the evolutionary causes of heritable variation. We are studying in particular the roles of dominance, epistasis, and linkage. C. elegans is an especially powerful system for studying the effects of linked selection because of its relatively low rate of outcrossing. We hope to study global patterns of epistasis by characterizing the additive and epistatic effects of large numbers of loci underlying gene expression traits that are under stabilizing selection. Alternate models for the mechanism of stabilizing selection — compensatory evolution and fluctuating neutral space — will be directly testable.
To incorporate ecological context into our understanding of heritable variation, we are planning extensive field work to characterize spatial and temporal dynamics of functional allele frequencies in C. elegans. In parallel, we are initiating work on a new model system, a widely distributed polychaete species with abundant heritable variation for developmental phenotypes. We can collect the polychaetes from sites across the exceptional marine and estuarine setting of the New York area and we are developing molecular tools to discover the loci underlying developmental variation and their distributions in nature.
研究兴趣
论文共 96 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Sophia C. Tintori, Derin Caglar, Patrick Ortiz, Ihor Chyzhevskyi,Timothy A. Mousseau,Matthew Rockman
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 11 (2024): e2314793121-e2314793121
bioRxiv : the preprint server for biology (2023)
引用0浏览0WOS引用
0
0
Sophia C. Tintori, Derin Çağlar, Patrick Ortiz,Ihor Chyzhevskyi,Timothy A. Mousseau,Matthew V. Rockman
bioRxiv : the preprint server for biology (2023)
引用0浏览0WOS引用
0
0
Journal of visualized experiments : JoVE (2022)
S. A. Sloat,L. M. Noble,A. B. Paaby, M. Bernstein,A. Chang,T. Kaur,J. Yuen,S. C. Tintori,J. L. Jackson,A. Martel, Salome J. A. Correa,L. Stevens,
Geneticsno. 1 (2022)
crossref(2021)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn