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职业迁徙
个人简介
My group sits at the intersection of genomics and neuroscience, utilising a number of genomic approaches (RNA-Seq, long-read sequencing, targeted RNA sequencing and single cell sequencing) to investigate gene expression and function in the human brain and in neuropsychiatric disorders. Many regions in our DNA are known to confer risk to disease, including neuropsychiatric disorders, but the genes responsible and how they confer risk are often unknown.
We are interested in identifying these genes (both protein coding and noncoding) and how their expression can change to cause disease risk. We utilise both post-mortem human brain and neurons derived from induced pluripotent stem cells (iPSCs) to help answer these questions.
A second research interest of my group is to develop and utilise novel sequencing methods. We have worked in the past to help develop targeted RNA sequencing to allow highly sensitive detection and quantification of genes of interest. More recently we have focused on utilising Nanopore sequencing, a technology that can sequence both DNA and native RNA. We are very interested in applying Nanopore sequencing to many research questions and in developing novel applications for this technology.
In addition I have long-standing interests in multiple aspects of RNA biology including noncoding RNAs and RNA post-transcriptional regulation.
We are interested in identifying these genes (both protein coding and noncoding) and how their expression can change to cause disease risk. We utilise both post-mortem human brain and neurons derived from induced pluripotent stem cells (iPSCs) to help answer these questions.
A second research interest of my group is to develop and utilise novel sequencing methods. We have worked in the past to help develop targeted RNA sequencing to allow highly sensitive detection and quantification of genes of interest. More recently we have focused on utilising Nanopore sequencing, a technology that can sequence both DNA and native RNA. We are very interested in applying Nanopore sequencing to many research questions and in developing novel applications for this technology.
In addition I have long-standing interests in multiple aspects of RNA biology including noncoding RNAs and RNA post-transcriptional regulation.
研究兴趣
论文共 65 篇作者统计合作学者相似作者
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Ricardo De Paoli-Iseppi, Shweta S Joshi,Josie Gleeson,Yair DJ Prawer,Yupei You, Ria Agarwal, Anran Li, Anthea Hull, Eloise M Whitehead, Yoonji Seo, Rhea Kujawa, Raphael Chang,
medrxiv(2024)
Ching Yin Wan, Jack Davis, Manveer Chauhan,Josie Gleeson,Yair D J Prawer,Ricardo De Paoli-Iseppi,Christine A Wells,Jarny Choi,Michael B Clark
Nucleic acids research (2024)
ACS APPLIED MATERIALS & INTERFACESno. 4 (2024): 4361-4374
biorxiv(2024)
Nature communicationsno. 1 (2023): 7616-7616
Genome Biologyno. 1 (2023)
引用29浏览0WOS引用
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Miguel Angel Berrocal-Rubio,Yair D.J Prawer,Marija Dinevska,Ricardo De Paoli-Iseppi,Samuel S. Widodo,Nadia Rajab,William De Nardo, Jeannette C. Hallab, Anran Li,Theo Mantamadiotis,Michael B. Clark,Christine A. Wells
crossref(2023)
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