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职业迁徙
个人简介
Our research activities include mechanistic studies of epigenetic gene silencing (resulting in tumor suppressor inactivation, arrested differentiation, and immune evasion), and the development of preclinical models to reactivate these silenced genes. Validation of these approaches includes correlative studies within clinical trials of DNA-hypomethylating drugs and other chromatin-modifying agents in acute myeloid leukemia (AML), in order to identify novel biomarkers predicting response to epigenetically active drugs (epi-drugs), and to better understand the genetic and epigenetic mechanisms of resistance to these therapies. Experimental techniques used in the lab include culturing of AML and lung cancer cells, and purification of primary leukemia blood blasts from patients receiving epi-drug therapies. Molecular biology techniques: DNA methylome analyses, RNA-seq, ATAC-seq, ChIP-seq etc.
研究兴趣
论文共 446 篇作者统计合作学者相似作者
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Gaia Gentile,Teresa Poggio,Antonella Catalano, Minna Voutilainen,Mari Lahnalampi, Marta Andrade-Martinez,Tobias Ma,Roman Sankowski, Lina Goncharenko,Stefan Tholen,Kyuho Han,David W Morgens,
Blood advances (2024)
American journal of hematologyno. 3 (2024): 486-489
Gaia Gentile,Teresa Poggio,Antonella Catalano, Minna Voutilainen,Mari Lahnalampi, Marta Andrade-Martinez,Tobias Ma,Roman Sankowski, Lina Goncharenko,Stefan Tholen,Kyuho Han,David W. Morgens,
Blood Advances (2024)
Gaia Gentile,Teresa Poggio,Antonella Catalano, Minna Voutilainen,Mari Lahnalampi, Marta Andrade-Martinez,Tobias Ma,Roman Sankowski, Lina Goncharenko,Stefan Tholen,Kyuho Han,David W. Morgens,
Blood Advances (2024)
Giulia Pelos,Marisa Riester,Jagriti Pal,Ksenia Myacheva,Isabelle Moneke, John Charles Rotondo,Michael Luebbert,Sven Diederichs
INTERNATIONAL JOURNAL OF CANCERno. 6 (2024): 1029-1042
Björn Hackanson,Kristi L. Bennett,Romulo M. Brena,Jinmai Jiang,Rainer Claus,Shih-Shih Chen, Nadya Blagitko-Dorfs, Katie Maharry,Susan P. Whitman,Thomas D. Schmittgen,Michael Lübbert,Guido Marcucci,
crossref(2023)
Leukemiano. 5 (2023): 1018-1027
Clinical Lymphoma Myeloma and Leukemia (2023): S187
Clinical Lymphoma, Myeloma & Leukemia (2023): S376-S377
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